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Exploring and exploiting the systemic effects of deregulated replication licensing.
Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG. Petrakis TG, et al. Among authors: gorgoulis vg. Semin Cancer Biol. 2016 Jun;37-38:3-15. doi: 10.1016/j.semcancer.2015.12.002. Epub 2015 Dec 17. Semin Cancer Biol. 2016. PMID: 26707000 Review.
Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.
Karakaidos P, Taraviras S, Vassiliou LV, Zacharatos P, Kastrinakis NG, Kougiou D, Kouloukoussa M, Nishitani H, Papavassiliou AG, Lygerou Z, Gorgoulis VG. Karakaidos P, et al. Among authors: gorgoulis vg. Am J Pathol. 2004 Oct;165(4):1351-65. doi: 10.1016/S0002-9440(10)63393-7. Am J Pathol. 2004. PMID: 15466399 Free PMC article.
Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG. Liontos M, et al. Among authors: gorgoulis vg. Cancer Res. 2007 Nov 15;67(22):10899-909. doi: 10.1158/0008-5472.CAN-07-2837. Cancer Res. 2007. PMID: 18006835
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex.
Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS, Zou Y, Margaritis LH, Boothman DA, Gonos ES. Trougakos IP, et al. Among authors: gorgoulis vg. Clin Cancer Res. 2009 Jan 1;15(1):48-59. doi: 10.1158/1078-0432.CCR-08-1805. Clin Cancer Res. 2009. PMID: 19118032 Free PMC article.
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.
Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos IP, Kolettas E, Georgakilas AG, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG. Sideridou M, et al. Among authors: gorgoulis vg. J Cell Biol. 2011 Dec 26;195(7):1123-40. doi: 10.1083/jcb.201108121. J Cell Biol. 2011. PMID: 22201124 Free PMC article.
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues.
Georgakopoulou EA, Tsimaratou K, Evangelou K, Fernandez Marcos PJ, Zoumpourlis V, Trougakos IP, Kletsas D, Bartek J, Serrano M, Gorgoulis VG. Georgakopoulou EA, et al. Among authors: gorgoulis vg. Aging (Albany NY). 2013 Jan;5(1):37-50. doi: 10.18632/aging.100527. Aging (Albany NY). 2013. PMID: 23449538 Free PMC article.
345 results