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Endothelial cells are not productively infected by SARS-CoV-2.
Schimmel L, Chew KY, Stocks CJ, Yordanov TE, Essebier P, Kulasinghe A, Monkman J, Dos Santos Miggiolaro AFR, Cooper C, de Noronha L, Schroder K, Lagendijk AK, Labzin LI, Short KR, Gordon EJ. Schimmel L, et al. Among authors: gordon ej. Clin Transl Immunology. 2021 Oct 24;10(10):e1350. doi: 10.1002/cti2.1350. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34721846 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 34004780
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
Arts JJ, Mahlandt EK, Grönloh ML, Schimmel L, Noordstra I, Gordon E, van Steen AC, Tol S, Walzog B, van Rijssel J, Nolte MA, Postma M, Khuon S, Heddleston JM, Wait E, Chew TL, Winter M, Montanez E, Goedhart J, van Buul JD. Arts JJ, et al. Elife. 2021 Aug 25;10:e66074. doi: 10.7554/eLife.66074. Elife. 2021. PMID: 34431475 Free PMC article.
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release.
Labzin LI, Chew KY, Eschke K, Wang X, Esposito T, Stocks CJ, Rae J, Patrick R, Mostafavi H, Hill B, Yordanov TE, Holley CL, Emming S, Fritzlar S, Mordant FL, Steinfort DP, Subbarao K, Nefzger CM, Lagendijk AK, Gordon EJ, Parton RG, Short KR, Londrigan SL, Schroder K. Labzin LI, et al. Among authors: gordon ej. Sci Signal. 2023 Apr 25;16(782):eabq1366. doi: 10.1126/scisignal.abq1366. Epub 2023 Apr 25. Sci Signal. 2023. PMID: 37098119
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Jin Y, Ding Y, Richards M, Kaakinen M, Giese W, Baumann E, Szymborska A, Rosa A, Nordling S, Schimmel L, Akmeriç EB, Pena A, Nwadozi E, Jamalpour M, Holstein K, Sáinz-Jaspeado M, Bernabeu MO, Welsh M, Gordon E, Franco CA, Vestweber D, Eklund L, Gerhardt H, Claesson-Welsh L. Jin Y, et al. Nat Cardiovasc Res. 2022 Dec 7;1(12):1156-1173. doi: 10.1038/s44161-022-00172-z. Nat Cardiovasc Res. 2022. PMID: 37936984 Free PMC article.
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice.
Karunakaran D, Nguyen MA, Geoffrion M, Vreeken D, Lister Z, Cheng HS, Otte N, Essebier P, Wyatt H, Kandiah JW, Jung R, Alenghat FJ, Mompeon A, Lee R, Pan C, Gordon E, Rasheed A, Lusis AJ, Liu P, Matic LP, Hedin U, Fish JE, Guo L, Kolodgie F, Virmani R, van Gils JM, Rayner KJ. Karunakaran D, et al. Circulation. 2021 Jan 12;143(2):163-177. doi: 10.1161/CIRCULATIONAHA.118.038379. Epub 2020 Nov 23. Circulation. 2021. PMID: 33222501
288 results