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A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells.
Pan X, Heacock ML, Abdulaziz EN, Violante S, Zuckerman AL, Shrestha N, Yao C, Goodman RP, Cross JR, Cracan V. Pan X, et al. Among authors: goodman rp. Nat Chem Biol. 2024 May;20(5):594-604. doi: 10.1038/s41589-023-01460-w. Epub 2023 Oct 26. Nat Chem Biol. 2024. PMID: 37884806 Free PMC article.
Hepatic NADH reductive stress underlies common variation in metabolic traits.
Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Goodman RP, et al. Nature. 2020 Jul;583(7814):122-126. doi: 10.1038/s41586-020-2337-2. Epub 2020 May 27. Nature. 2020. PMID: 32461692 Free PMC article.
ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.
Singh C, Jin B, Shrestha N, Markhard AL, Panda A, Calvo SE, Deik A, Pan X, Zuckerman AL, Ben Saad A, Corey KE, Sjoquist J, Osganian S, AminiTabrizi R, Rhee EP, Shah H, Goldberger O, Mullen AC, Cracan V, Clish CB, Mootha VK, Goodman RP. Singh C, et al. Among authors: goodman rp. Cell Metab. 2024 Jan 2;36(1):144-158.e7. doi: 10.1016/j.cmet.2023.11.010. Epub 2023 Dec 14. Cell Metab. 2024. PMID: 38101397
Serum Fibroblast Growth Factor-21 Discriminates Between Decompensated Alcohol-Associated Cirrhosis and Severe Alcohol-Associated Hepatitis.
McLean Diaz P, Vannier A, Joshi AD, Mahle RE, Przybyszewski EM, Corey K, Chung RT, Luther J, Goodman RP, Schaefer EAK. McLean Diaz P, et al. Among authors: goodman rp. Clin Transl Gastroenterol. 2023 Jun 1;14(6):e00585. doi: 10.14309/ctg.0000000000000585. Clin Transl Gastroenterol. 2023. PMID: 36972232 Free PMC article.
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.
Skinner OS, Blanco-Fernández J, Goodman RP, Kawakami A, Shen H, Kemény LV, Joesch-Cohen L, Rees MG, Roth JA, Fisher DE, Mootha VK, Jourdain AA. Skinner OS, et al. Among authors: goodman rp. Nat Metab. 2023 May;5(5):765-776. doi: 10.1038/s42255-023-00774-2. Epub 2023 May 17. Nat Metab. 2023. PMID: 37198474 Free PMC article.
Clinical Genetic Testing in Gastroenterology.
Goodman RP, Chung DC. Goodman RP, et al. Clin Transl Gastroenterol. 2016 Apr 28;7(4):e167. doi: 10.1038/ctg.2016.23. Clin Transl Gastroenterol. 2016. PMID: 27124700 Free PMC article. Review.
67 results