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Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome.
Zhang Y, Kremsdorf RA, Sperati CJ, Henriksen KJ, Mori M, Goodfellow RX, Pitcher GR, Benson CL, Borsa NG, Taylor RP, Nester CM, Smith RJH. Zhang Y, et al. Among authors: goodfellow rx. Kidney Int. 2020 Nov;98(5):1265-1274. doi: 10.1016/j.kint.2020.05.028. Epub 2020 Jun 12. Kidney Int. 2020. PMID: 32540405 Free PMC article.
Complement Factor I Variants in Complement-Mediated Renal Diseases.
Zhang Y, Goodfellow RX, Ghiringhelli Borsa N, Dunlop HC, Presti SA, Meyer NC, Shao D, Roberts SM, Jones MB, Pitcher GR, Taylor AO, Nester CM, Smith RJH. Zhang Y, et al. Among authors: goodfellow rx. Front Immunol. 2022 May 10;13:866330. doi: 10.3389/fimmu.2022.866330. eCollection 2022. Front Immunol. 2022. PMID: 35619721 Free PMC article.
Renin and renin blockade have no role in complement activity.
Zhang Y, Martin B, Spies MA, Roberts SM, Nott J, Goodfellow RX, Nelson AFM, Blain SJ, Redondo E, Nester CM, Smith RJH. Zhang Y, et al. Among authors: goodfellow rx. Kidney Int. 2024 Feb;105(2):328-337. doi: 10.1016/j.kint.2023.11.005. Epub 2023 Nov 25. Kidney Int. 2024. PMID: 38008161 Free article.