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Dnmt3a is essential for hematopoietic stem cell differentiation.
Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Challen GA, et al. Among authors: goodell ma. Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009. Nat Genet. 2011. PMID: 22138693 Free PMC article.
Large conserved domains of low DNA methylation maintained by Dnmt3a.
Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Jeong M, et al. Among authors: goodell ma. Nat Genet. 2014 Jan;46(1):17-23. doi: 10.1038/ng.2836. Epub 2013 Nov 24. Nat Genet. 2014. PMID: 24270360 Free PMC article.
DNMT3A in haematological malignancies.
Yang L, Rau R, Goodell MA. Yang L, et al. Among authors: goodell ma. Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19. Nat Rev Cancer. 2015. PMID: 25693834 Free PMC article. Review.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. Yang L, et al. Among authors: goodell ma. Cancer Cell. 2016 Jun 13;29(6):922-934. doi: 10.1016/j.ccell.2016.05.003. Cancer Cell. 2016. PMID: 27300438 Free PMC article.
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. Rau RE, et al. Among authors: goodell ma. Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22. Blood. 2016. PMID: 27335278 Free PMC article.
DNMT3A in Leukemia.
Brunetti L, Gundry MC, Goodell MA. Brunetti L, et al. Among authors: goodell ma. Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a030320. doi: 10.1101/cshperspect.a030320. Cold Spring Harb Perspect Med. 2017. PMID: 28003281 Free PMC article. Review.
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
Jeong M, Park HJ, Celik H, Ostrander EL, Reyes JM, Guzman A, Rodriguez B, Lei Y, Lee Y, Ding L, Guryanova OA, Li W, Goodell MA, Challen GA. Jeong M, et al. Among authors: goodell ma. Cell Rep. 2018 Apr 3;23(1):1-10. doi: 10.1016/j.celrep.2018.03.025. Cell Rep. 2018. PMID: 29617651 Free PMC article.
Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA. Brunetti L, et al. Among authors: goodell ma. Cancer Cell. 2018 Sep 10;34(3):499-512.e9. doi: 10.1016/j.ccell.2018.08.005. Cancer Cell. 2018. PMID: 30205049 Free PMC article.
195 results