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Megalin binds and internalizes angiotensin-(1-7).
Gonzalez-Villalobos R, Klassen RB, Allen PL, Johanson K, Baker CB, Kobori H, Navar LG, Hammond TG. Gonzalez-Villalobos R, et al. Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5. doi: 10.1152/ajprenal.00164.2005. Epub 2005 Dec 27. Am J Physiol Renal Physiol. 2006. PMID: 16380466 Free PMC article.
Megalin binds and internalizes angiotensin II.
Gonzalez-Villalobos R, Klassen RB, Allen PL, Navar LG, Hammond TG. Gonzalez-Villalobos R, et al. Am J Physiol Renal Physiol. 2005 Feb;288(2):F420-7. doi: 10.1152/ajprenal.00243.2004. Epub 2004 Oct 5. Am J Physiol Renal Physiol. 2005. PMID: 15467006 Free article.
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans.
Kobori H, Fu Q, Crowley SD, Gonzalez-Villalobos RA, Campos RR. Kobori H, et al. J Appl Physiol (1985). 2010 Dec;109(6):2003. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21148352 Free PMC article. No abstract available.
Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats.
Prieto MC, González-Villalobos RA, Botros FT, Martin VL, Pagán J, Satou R, Lara LS, Feng Y, Fernandes FB, Kobori H, Casarini DE, Navar LG. Prieto MC, et al. Am J Physiol Renal Physiol. 2011 Mar;300(3):F749-55. doi: 10.1152/ajprenal.00383.2009. Epub 2011 Jan 5. Am J Physiol Renal Physiol. 2011. PMID: 21209009 Free PMC article.
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