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Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore.
García-Aranda MI, Gonzalez-Padilla JE, Gómez-Castro CZ, Gómez-Gómez YM, Rosales-Hernández MC, García-Báez EV, Franco-Hernández MO, Castrejón-Flores JL, Padilla-Martínez II. García-Aranda MI, et al. Among authors: gonzalez padilla je. Bioorg Med Chem. 2020 May 1;28(9):115427. doi: 10.1016/j.bmc.2020.115427. Epub 2020 Mar 21. Bioorg Med Chem. 2020. PMID: 32205045
π-stacking and C-X...D (X = H, NO2; D = O, π) interactions in the crystal network of both C-H...N and π-stacked dimers of 1,2-bis(4-bromophenyl)-1H-benzimidazole and 2-(4-bromophenyl)-1-(4-nitrophenyl)-1H-benzimidazole.
González-Padilla JE, Rosales-Hernández MC, Padilla-Martínez II, García-Báez EV, Rojas-Lima S, Salazar-Pereda V. González-Padilla JE, et al. Acta Crystallogr C Struct Chem. 2014 Jan;70(Pt 1):55-9. doi: 10.1107/S2053229613033329. Epub 2013 Dec 21. Acta Crystallogr C Struct Chem. 2014. PMID: 24399227
2-(4-Hy-droxy-phen-yl)-1H-benzimidazol-3-ium chloride monohydrate.
González-Padilla JE, Rosales-Hernández MC, Padilla-Martínez II, García-Báez EV, Rojas-Lima S. González-Padilla JE, et al. Acta Crystallogr Sect E Struct Rep Online. 2013 Aug 31;69(Pt 9):o1485-6. doi: 10.1107/S1600536813023441. eCollection 2013. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 24427105 Free PMC article.