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G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage.
NPJ Parkinsons Dis. 2024 Mar 1;10(1):49. doi: 10.1038/s41531-024-00660-y.
NPJ Parkinsons Dis. 2024.
PMID: 38429321
Free PMC article.
A blood-based marker of mitochondrial DNA damage in Parkinson's disease.
Qi R, Sammler E, Gonzalez-Hunt CP, Barraza I, Pena N, Rouanet JP, Naaldijk Y, Goodson S, Fuzzati M, Blandini F, Erickson KI, Weinstein AM, Lutz MW, Kwok JB, Halliday GM, Dzamko N, Padmanabhan S, Alcalay RN, Waters C, Hogarth P, Simuni T, Smith D, Marras C, Tonelli F, Alessi DR, West AB, Shiva S, Hilfiker S, Sanders LH.
Qi R, et al. Among authors: gonzalez hunt cp.
Sci Transl Med. 2023 Aug 30;15(711):eabo1557. doi: 10.1126/scitranslmed.abo1557. Epub 2023 Aug 30.
Sci Transl Med. 2023.
PMID: 37647388
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Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.
Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, Hirschey MD, Meyer JN.
Gonzalez-Hunt CP, et al.
Toxicology. 2021 Jan 15;447:152630. doi: 10.1016/j.tox.2020.152630. Epub 2020 Nov 11.
Toxicology. 2021.
PMID: 33188857
Free PMC article.
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Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease.
Gonzalez-Hunt CP, Thacker EA, Toste CM, Boularand S, Deprets S, Dubois L, Sanders LH.
Gonzalez-Hunt CP, et al.
Sci Rep. 2020 Oct 14;10(1):17293. doi: 10.1038/s41598-020-74195-6.
Sci Rep. 2020.
PMID: 33057100
Free PMC article.
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DNA damage and repair in Parkinson's disease: Recent advances and new opportunities.
Gonzalez-Hunt CP, Sanders LH.
Gonzalez-Hunt CP, et al.
J Neurosci Res. 2021 Jan;99(1):180-189. doi: 10.1002/jnr.24592. Epub 2020 Feb 12.
J Neurosci Res. 2021.
PMID: 32048327
Review.
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PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage.
Gonzalez-Hunt CP, Rooney JP, Ryde IT, Anbalagan C, Joglekar R, Meyer JN.
Gonzalez-Hunt CP, et al.
Curr Protoc Toxicol. 2016 Feb 1;67:20.11.1-20.11.25. doi: 10.1002/0471140856.tx2011s67.
Curr Protoc Toxicol. 2016.
PMID: 26828332
Free PMC article.
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Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans.
González-Hunt CP, Leung MC, Bodhicharla RK, McKeever MG, Arrant AE, Margillo KM, Ryde IT, Cyr DD, Kosmaczewski SG, Hammarlund M, Meyer JN.
González-Hunt CP, et al.
PLoS One. 2014 Dec 8;9(12):e114459. doi: 10.1371/journal.pone.0114459. eCollection 2014.
PLoS One. 2014.
PMID: 25486066
Free PMC article.
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Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans.
Rooney JP, Luz AL, González-Hunt CP, Bodhicharla R, Ryde IT, Anbalagan C, Meyer JN.
Rooney JP, et al. Among authors: gonzalez hunt cp.
Exp Gerontol. 2014 Aug;56:69-76. doi: 10.1016/j.exger.2014.03.021. Epub 2014 Apr 3.
Exp Gerontol. 2014.
PMID: 24704715
Free PMC article.
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