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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Gu L, et al. Among authors: gonzalez dj. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. Cell Metab. 2023. PMID: 37084733 Free PMC article.
Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion.
Wierzbicki IH, Campeau A, Dehaini D, Holay M, Wei X, Greene T, Ying M, Sands JS, Lamsa A, Zuniga E, Pogliano K, Fang RH, LaRock CN, Zhang L, Gonzalez DJ. Wierzbicki IH, et al. Among authors: gonzalez dj. Cell Rep. 2019 Dec 3;29(10):2979-2989.e15. doi: 10.1016/j.celrep.2019.11.001. Cell Rep. 2019. PMID: 31801066 Free PMC article.
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: gonzalez dj. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.
Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. Pilo CA, et al. Among authors: gonzalez dj. Sci Signal. 2022 Sep 27;15(753):eabk1147. doi: 10.1126/scisignal.abk1147. Epub 2022 Sep 27. Sci Signal. 2022. PMID: 36166510 Free PMC article.
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.
Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. Grimsey NJ, et al. Among authors: gonzalez dj. Cell Rep. 2018 Sep 18;24(12):3312-3323.e5. doi: 10.1016/j.celrep.2018.08.061. Cell Rep. 2018. PMID: 30232011 Free PMC article.
EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells.
Grainger S, Nguyen N, Richter J, Setayesh J, Lonquich B, Oon CH, Wozniak JM, Barahona R, Kamei CN, Houston J, Carrillo-Terrazas M, Drummond IA, Gonzalez D, Willert K, Traver D. Grainger S, et al. Nat Cell Biol. 2019 Jun;21(6):721-730. doi: 10.1038/s41556-019-0330-5. Epub 2019 May 20. Nat Cell Biol. 2019. PMID: 31110287 Free PMC article.
Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes.
Russell BJ, Brown SD, Siguenza N, Mai I, Saran AR, Lingaraju A, Maissy ES, Dantas Machado AC, Pinto AFM, Sanchez C, Rossitto LA, Miyamoto Y, Richter RA, Ho SB, Eckmann L, Hasty J, Gonzalez DJ, Saghatelian A, Knight R, Zarrinpar A. Russell BJ, et al. Among authors: gonzalez dj. Cell. 2022 Aug 18;185(17):3263-3277.e15. doi: 10.1016/j.cell.2022.06.050. Epub 2022 Aug 4. Cell. 2022. PMID: 35931082 Free PMC article.
140 results