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Conformational buffering underlies functional selection in intrinsically disordered protein regions.
González-Foutel NS, Glavina J, Borcherds WM, Safranchik M, Barrera-Vilarmau S, Sagar A, Estaña A, Barozet A, Garrone NA, Fernandez-Ballester G, Blanes-Mira C, Sánchez IE, de Prat-Gay G, Cortés J, Bernadó P, Pappu RV, Holehouse AS, Daughdrill GW, Chemes LB. González-Foutel NS, et al. Nat Struct Mol Biol. 2022 Aug;29(8):781-790. doi: 10.1038/s41594-022-00811-w. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948766 Free PMC article.
Critical assessment of protein intrinsic disorder prediction.
Necci M, Piovesan D; CAID Predictors; DisProt Curators; Tosatto SCE. Necci M, et al. Nat Methods. 2021 May;18(5):472-481. doi: 10.1038/s41592-021-01117-3. Epub 2021 Apr 19. Nat Methods. 2021. PMID: 33875885 Free PMC article.
The optimal docking strength for reversibly tethered kinases.
Dyla M, González Foutel NS, Otzen DE, Kjaergaard M. Dyla M, et al. Among authors: gonzalez foutel ns. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2203098119. doi: 10.1073/pnas.2203098119. Epub 2022 Jun 13. Proc Natl Acad Sci U S A. 2022. PMID: 35696590 Free PMC article.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.
Lü Y, Cho T, Mukherjee S, Suarez CF, Gonzalez-Foutel NS, Malik A, Martinez S, Dervovic D, Oh RH, Langille E, Al-Zahrani KN, Hoeg L, Lin ZY, Tsai R, Mbamalu G, Rotter V, Ashton-Prolla P, Moffat J, Chemes LB, Gingras AC, Oren M, Durocher D, Schramek D. Lü Y, et al. Among authors: gonzalez foutel ns. Mol Syst Biol. 2024 Apr 5. doi: 10.1038/s44320-024-00032-x. Online ahead of print. Mol Syst Biol. 2024. PMID: 38580884 Free article.
Design of functional intrinsically disordered proteins.
Garg A, González-Foutel NS, Gielnik MB, Kjaergaard M. Garg A, et al. Among authors: gonzalez foutel ns. Protein Eng Des Sel. 2024 Jan 29;37:gzae004. doi: 10.1093/protein/gzae004. Protein Eng Des Sel. 2024. PMID: 38431892