González-Álvarez I - Search Results

1

Segmental-Dependent Solubility and Permeability as Key Factors Guiding Controlled Release Drug Product Development.

Markovic M, Zur M, Fine-Shamir N, Haimov E, González-Álvarez I, Dahan A. Markovic M, et al. Pharmaceutics. 2020 Mar 24;12(3):295. doi: 10.3390/pharmaceutics12030295. Pharmaceutics. 2020. PMID: 32214015 Free PMC article.

2

Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier.

Mangas-Sanjuan V, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M. Mangas-Sanjuan V, et al. Mol Pharm. 2013 Oct 7;10(10):3822-31. doi: 10.1021/mp400294x. Epub 2013 Sep 9. Mol Pharm. 2013. PMID: 23977999

3

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

Mangas-Sanjuan V, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M. Mangas-Sanjuan V, et al. Mol Pharm. 2014 May 5;11(5):1403-14. doi: 10.1021/mp400555e. Epub 2014 Apr 7. Mol Pharm. 2014. PMID: 24665996

4

In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches.

Lozoya-Agullo I, Zur M, Wolk O, Beig A, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A. Lozoya-Agullo I, et al. Int J Pharm. 2015 Mar 1;480(1-2):1-7. doi: 10.1016/j.ijpharm.2015.01.014. Epub 2015 Jan 13. Int J Pharm. 2015. PMID: 25595387

5

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

Colón-Useche S, González-Álvarez I, Mangas-Sanjuan V, González-Álvarez M, Pastoriza P, Molina-Martínez I, Bermejo M, García-Arieta A. Colón-Useche S, et al. Mol Pharm. 2015 Sep 8;12(9):3167-74. doi: 10.1021/acs.molpharmaceut.5b00076. Epub 2015 Aug 26. Mol Pharm. 2015. PMID: 26287948

6

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.

Lozoya-Agullo I, Zur M, Beig A, Fine N, Cohen Y, González-Álvarez M, Merino-Sanjuán M, González-Álvarez I, Bermejo M, Dahan A. Lozoya-Agullo I, et al. Int J Pharm. 2016 Dec 30;515(1-2):201-208. doi: 10.1016/j.ijpharm.2016.09.061. Epub 2016 Sep 22. Int J Pharm. 2016. PMID: 27667756

7

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture.

Lozoya-Agullo I, Araújo F, González-Álvarez I, Merino-Sanjuán M, González-Álvarez M, Bermejo M, Sarmento B. Lozoya-Agullo I, et al. Mol Pharm. 2017 Apr 3;14(4):1264-1270. doi: 10.1021/acs.molpharmaceut.6b01165. Epub 2017 Mar 10. Mol Pharm. 2017. PMID: 28263609

8

Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.

Lozoya-Agullo I, Zur M, Fine-Shamir N, Markovic M, Cohen Y, Porat D, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A. Lozoya-Agullo I, et al. Int J Pharm. 2017 Jul 15;527(1-2):135-141. doi: 10.1016/j.ijpharm.2017.05.018. Epub 2017 May 10. Int J Pharm. 2017. PMID: 28501438

9

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.

Lozoya-Agullo I, Gonzalez-Alvarez I, Zur M, Fine-Shamir N, Cohen Y, Markovic M, Garrigues TM, Dahan A, Gonzalez-Alvarez M, Merino-Sanjuán M, Bermejo M, Avdeef A. Lozoya-Agullo I, et al. Pharm Res. 2017 Dec 29;35(1):2. doi: 10.1007/s11095-017-2331-z. Pharm Res. 2017. PMID: 29288412

10

In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC.

Ruiz Picazo A, Martinez-Martinez MT, Colón-Useche S, Iriarte R, Sánchez-Dengra B, González-Álvarez M, García-Arieta A, González-Álvarez I, Bermejo M. Ruiz Picazo A, et al. Mol Pharm. 2018 Jun 4;15(6):2307-2315. doi: 10.1021/acs.molpharmaceut.8b00153. Epub 2018 May 17. Mol Pharm. 2018. PMID: 29746133 Clinical Trial.

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