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Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: gonzalez jm, gonzalez mm. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303030 Free PMC article.
The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site.
Morán-Barrio J, González JM, Lisa MN, Costello AL, Peraro MD, Carloni P, Bennett B, Tierney DL, Limansky AS, Viale AM, Vila AJ. Morán-Barrio J, et al. Among authors: gonzalez jm. J Biol Chem. 2007 Jun 22;282(25):18286-18293. doi: 10.1074/jbc.M700467200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403673 Free article.
1,124 results