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Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects.
Prado-Acosta M, Jeong S, Utrero-Rico A, Goncharov T, Webster JD, Holler E, Morales G, Dellepiane S, Levine JE, Rothenberg ME, Vucic D, Ferrara JLM. Prado-Acosta M, et al. Among authors: goncharov t. Sci Transl Med. 2023 Dec 20;15(727):eadf8366. doi: 10.1126/scitranslmed.adf8366. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117900
XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death.
Witt A, Goncharov T, Lee YM, Kist M, Dohse M, Eastham J, Dugger D, Newton K, Webster JD, Vucic D. Witt A, et al. Among authors: goncharov t. Cell Death Dis. 2023 Apr 11;14(4):262. doi: 10.1038/s41419-023-05793-1. Cell Death Dis. 2023. PMID: 37041175 Free PMC article.
Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.
den Besten W, Verma K, Yamazoe S, Blaquiere N, Phung W, Izrael-Tomasevic A, Mulvihill MM, Helgason E, Prakash S, Goncharov T, Vucic D, Dueber E, Fairbrother WJ, Wertz I, Yu K, Staben ST. den Besten W, et al. Among authors: goncharov t. J Am Chem Soc. 2021 Jul 21;143(28):10571-10575. doi: 10.1021/jacs.1c05269. Epub 2021 Jul 8. J Am Chem Soc. 2021. PMID: 34236858
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury.
Stark K, Goncharov T, Varfolomeev E, Xie L, Ngu H, Peng I, Anderson KR, Verschueren E, Choi M, Kirkpatrick DS, Easton A, Webster JD, McKenzie BS, Vucic D, Bingol B. Stark K, et al. Among authors: goncharov t. Cell Death Dis. 2021 Apr 7;12(4):379. doi: 10.1038/s41419-021-03651-6. Cell Death Dis. 2021. PMID: 33828080 Free PMC article.
RIP1 kinase activity is critical for skin inflammation but not for viral propagation.
Webster JD, Kwon YC, Park S, Zhang H, Corr N, Ljumanovic N, Adedeji AO, Varfolomeev E, Goncharov T, Preston J, Santagostino SF, Patel S, Xu M, Maher J, McKenzie BS, Vucic D. Webster JD, et al. Among authors: goncharov t. J Leukoc Biol. 2020 Jun;107(6):941-952. doi: 10.1002/JLB.3MA1219-398R. Epub 2020 Jan 27. J Leukoc Biol. 2020. PMID: 31985117 Free PMC article.
30 results