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Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.
Gomes JC, Cianni L, Ribeiro J, Dos Reis Rocho F, da Costa Martins Silva S, Batista PHJ, Moraes CB, Franco CH, Freitas-Junior LHG, Kenny PW, Leitão A, Burtoloso ACB, de Vita D, Montanari CA. Gomes JC, et al. Bioorg Med Chem. 2019 Nov 15;27(22):115083. doi: 10.1016/j.bmc.2019.115083. Epub 2019 Aug 28. Bioorg Med Chem. 2019. PMID: 31561938
Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors.
Burtoloso AC, de Albuquerque S, Furber M, Gomes JC, Gonçalez C, Kenny PW, Leitão A, Montanari CA, Quilles JC Júnior, Ribeiro JF, Rocha JR. Burtoloso AC, et al. Among authors: gomes jc. PLoS Negl Trop Dis. 2017 Feb 21;11(2):e0005343. doi: 10.1371/journal.pntd.0005343. eCollection 2017 Feb. PLoS Negl Trop Dis. 2017. PMID: 28222138 Free PMC article.
Inhibition of O-GlcNAcylation Reduces Cell Viability and Autophagy and Increases Sensitivity to Chemotherapeutic Temozolomide in Glioblastoma.
Leonel AV, Alisson-Silva F, Santos RCM, Silva-Aguiar RP, Gomes JC, Longo GMC, Faria BM, Siqueira MS, Pereira MG, Vasconcelos-Dos-Santos A, Chiarini LB, Slawson C, Caruso-Neves C, Romão L, Travassos LH, Carneiro K, Todeschini AR, Dias WB. Leonel AV, et al. Among authors: gomes jc. Cancers (Basel). 2023 Sep 27;15(19):4740. doi: 10.3390/cancers15194740. Cancers (Basel). 2023. PMID: 37835434 Free PMC article.
121 results