Gokhale R - Search Results

1

Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents.

Ramesh R, Shingare RD, Kumar V, Anand A, B S, Veeraraghavan S, Viswanadha S, Ummanni R, Gokhale R, Srinivasa Reddy D. Ramesh R, et al. Among authors: gokhale r. Eur J Med Chem. 2016 Oct 21;122:723-730. doi: 10.1016/j.ejmech.2016.07.009. Epub 2016 Jul 9. Eur J Med Chem. 2016. PMID: 27476117

2

Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches.

Anand A, Verma P, Singh AK, Kaushik S, Pandey R, Shi C, Kaur H, Chawla M, Elechalawar CK, Kumar D, Yang Y, Bhavesh NS, Banerjee R, Dash D, Singh A, Natarajan VT, Ojha AK, Aldrich CC, Gokhale RS. Anand A, et al. Among authors: gokhale rs. Mol Cell. 2015 Nov 19;60(4):637-50. doi: 10.1016/j.molcel.2015.10.016. Epub 2015 Nov 12. Mol Cell. 2015. PMID: 26585386 Free PMC article.

3

Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors: An effective strategy towards development of potent anti-tubercular agents.

Vasudevan N, Motiwala Z, Ramesh R, Wagh SB, Shingare RD, Katte R, Anand A, Choudhary S, Kumar A, Gokhale RS, Kulkarni KA, Reddy DS. Vasudevan N, et al. Among authors: gokhale rs. Eur J Med Chem. 2023 Nov 5;259:115633. doi: 10.1016/j.ejmech.2023.115633. Epub 2023 Jul 16. Eur J Med Chem. 2023. PMID: 37524010

4

Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues.

Swaroop PS, Raut GN, Gonnade RG, Verma P, Gokhale RS, Reddy DS. Swaroop PS, et al. Org Biomol Chem. 2012 Jul 28;10(28):5385-94. doi: 10.1039/c2ob25831e. Epub 2012 May 25. Org Biomol Chem. 2012. PMID: 22627490

5

Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase.

Srivastava S, Chaudhary S, Thukral L, Shi C, Gupta RD, Gupta R, Priyadarshan K, Vats A, Haque AS, Sankaranarayanan R, Natarajan VT, Sharma R, Aldrich CC, Gokhale RS. Srivastava S, et al. Among authors: gokhale rs. Chem Biol. 2015 Dec 17;22(12):1577-87. doi: 10.1016/j.chembiol.2015.10.009. Epub 2015 Nov 25. Chem Biol. 2015. PMID: 26628360

6

Retrobiosynthetic approach delineates the biosynthetic pathway and the structure of the acyl chain of mycobacterial glycopeptidolipids.

Vats A, Singh AK, Mukherjee R, Chopra T, Ravindran MS, Mohanty D, Chatterji D, Reyrat JM, Gokhale RS. Vats A, et al. Among authors: gokhale rs. J Biol Chem. 2012 Aug 31;287(36):30677-87. doi: 10.1074/jbc.M112.384966. Epub 2012 Jul 13. J Biol Chem. 2012. PMID: 22798073 Free PMC article.

7

Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA σ-anti-σ complex.

Shukla J, Gupta R, Thakur KG, Gokhale R, Gopal B. Shukla J, et al. Among authors: gokhale r. Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):1026-36. doi: 10.1107/S1399004714000121. Epub 2014 Mar 19. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24699647

8

Phospholipid homeostasis, membrane tenacity and survival of Mtb in lipid rich conditions is determined by MmpL11 function.

Bothra A, Arumugam P, Panchal V, Menon D, Srivastava S, Shankaran D, Nandy A, Jaisinghani N, Singh A, Gokhale RS, Gandotra S, Rao V. Bothra A, et al. Sci Rep. 2018 May 29;8(1):8317. doi: 10.1038/s41598-018-26710-z. Sci Rep. 2018. PMID: 29844505 Free PMC article.

9

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation.

Patil GS, Kinatukara P, Mondal S, Shambhavi S, Patel KD, Pramanik S, Dubey N, Narasimhan S, Madduri MK, Pal B, Gokhale RS, Sankaranarayanan R. Patil GS, et al. Among authors: gokhale rs. Elife. 2021 Sep 7;10:e70067. doi: 10.7554/eLife.70067. Elife. 2021. PMID: 34490847 Free PMC article.

10

Structural insights into the regulation of NADPH binding to reductase domains of nonribosomal peptide synthetases: A concerted loop movement model.

Kinatukara P, Patel KD, Haque AS, Singh R, Gokhale RS, Sankaranarayananan R. Kinatukara P, et al. Among authors: gokhale rs. J Struct Biol. 2016 Jun;194(3):368-74. doi: 10.1016/j.jsb.2016.03.014. Epub 2016 Mar 16. J Struct Biol. 2016. PMID: 26993465

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