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Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
Jett KA, Baker ZN, Hossain A, Boulet A, Cobine PA, Ghosh S, Ng P, Yilmaz O, Barreto K, DeCoteau J, Mochoruk K, Ioannou GN, Savard C, Yuan S, Abdalla OH, Lowden C, Kim BE, Cheng HM, Battersby BJ, Gohil VM, Leary SC. Jett KA, et al. Among authors: gohil vm. J Clin Invest. 2023 Jan 3;133(1):e154684. doi: 10.1172/JCI154684. J Clin Invest. 2023. PMID: 36301669 Free PMC article.
Elesclomol restores mitochondrial function in genetic models of copper deficiency.
Soma S, Latimer AJ, Chun H, Vicary AC, Timbalia SA, Boulet A, Rahn JJ, Chan SSL, Leary SC, Kim BE, Gitlin JD, Gohil VM. Soma S, et al. Among authors: gohil vm. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8161-8166. doi: 10.1073/pnas.1806296115. Epub 2018 Jul 23. Proc Natl Acad Sci U S A. 2018. PMID: 30038027 Free PMC article.
Mitochondrial dysfunctions in barth syndrome.
Ghosh S, Iadarola DM, Ball WB, Gohil VM. Ghosh S, et al. Among authors: gohil vm. IUBMB Life. 2019 Jul;71(7):791-801. doi: 10.1002/iub.2018. Epub 2019 Feb 11. IUBMB Life. 2019. PMID: 30746873 Free PMC article. Review.
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice.
Guthrie LM, Soma S, Yuan S, Silva A, Zulkifli M, Snavely TC, Greene HF, Nunez E, Lynch B, De Ville C, Shanbhag V, Lopez FR, Acharya A, Petris MJ, Kim BE, Gohil VM, Sacchettini JC. Guthrie LM, et al. Among authors: gohil vm. Science. 2020 May 8;368(6491):620-625. doi: 10.1126/science.aaz8899. Science. 2020. PMID: 32381719 Free PMC article.
Connecting copper and cancer: from transition metal signalling to metalloplasia.
Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ. Ge EJ, et al. Among authors: gohil vm. Nat Rev Cancer. 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. Nat Rev Cancer. 2022. PMID: 34764459 Free PMC article. Review.
54 results