Gohda K - Search Results

1

Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum.

Teno N, Iguchi Y, Oda K, Yamashita Y, Masuda A, Fujimori K, Une M, Gohda K. Teno N, et al. Among authors: gohda k. ACS Med Chem Lett. 2021 Feb 24;12(3):420-425. doi: 10.1021/acsmedchemlett.0c00640. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738070 Free PMC article.

2

NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity.

Shimamoto S, Yoshida T, Inui T, Gohda K, Kobayashi Y, Fujimori K, Tsurumura T, Aritake K, Urade Y, Ohkubo T. Shimamoto S, et al. Among authors: gohda k. J Biol Chem. 2007 Oct 26;282(43):31373-9. doi: 10.1074/jbc.M700123200. Epub 2007 Aug 22. J Biol Chem. 2007. PMID: 17715133 Free article.

3

Novel scaffold for cathepsin K inhibitors.

Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C. Teno N, et al. Among authors: gohda k. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. doi: 10.1016/j.bmcl.2007.09.047. Epub 2007 Sep 15. Bioorg Med Chem Lett. 2007. PMID: 17911019

4

New chemotypes for cathepsin K inhibitors.

Teno N, Irie O, Miyake T, Gohda K, Horiuchi M, Tada S, Nonomura K, Kometani M, Iwasaki G, Betschart C. Teno N, et al. Among authors: gohda k. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2599-603. doi: 10.1016/j.bmcl.2008.03.036. Epub 2008 Mar 16. Bioorg Med Chem Lett. 2008. PMID: 18375120

5

Species differences between human and rat in the substrate specificity of cathepsin K.

Tada S, Tsutsumi K, Ishihara H, Suzuki K, Gohda K, Teno N. Tada S, et al. Among authors: gohda k. J Biochem. 2008 Oct;144(4):499-506. doi: 10.1093/jb/mvn093. Epub 2008 Jul 29. J Biochem. 2008. PMID: 18664521

6

Identification of novel plasmin inhibitors possessing nitrile moiety as warhead.

Teno N, Gohda K, Wanaka K, Sueda T, Tsuda Y. Teno N, et al. Among authors: gohda k. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6305-9. doi: 10.1016/j.bmcl.2011.08.121. Epub 2011 Sep 1. Bioorg Med Chem Lett. 2011. PMID: 21944858

7

Predicting subsite interactions of plasmin with substrates and inhibitors through computational docking analysis.

Gohda K, Teno N, Wanaka K, Tsuda Y. Gohda K, et al. J Enzyme Inhib Med Chem. 2012 Aug;27(4):571-7. doi: 10.3109/14756366.2011.603129. Epub 2011 Oct 12. J Enzyme Inhib Med Chem. 2012. PMID: 21992704

8

Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead.

Teno N, Otsubo T, Gohda K, Wanaka K, Sueda T, Ikeda K, Hijikata-Okunomiya A, Tsuda Y. Teno N, et al. Among authors: gohda k. J Pept Sci. 2012 Oct;18(10):620-5. doi: 10.1002/psc.2442. Epub 2012 Sep 7. J Pept Sci. 2012. PMID: 22961872

9

Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells.

Gohda K, Fujimori K, Teno N, Wanaka K, Tsuda Y. Gohda K, et al. Chem Biol Drug Des. 2014 Jan;83(1):52-7. doi: 10.1111/cbdd.12232. Epub 2013 Oct 30. Chem Biol Drug Des. 2014. PMID: 24112688

10

Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.

Teno N, Gohda K, Wanaka K, Tsuda Y, Sueda T, Yamashita Y, Otsubo T. Teno N, et al. Among authors: gohda k. Bioorg Med Chem. 2014 Apr 1;22(7):2339-52. doi: 10.1016/j.bmc.2014.02.002. Epub 2014 Feb 24. Bioorg Med Chem. 2014. PMID: 24613052

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