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Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Wang H, Yu N, Chen D, Lee KC, Lye PL, Chang JW, Deng W, Ng MC, Lu T, Khoo ML, Poulsen A, Sangthongpitag K, Wu X, Hu C, Goh KC, Wang X, Fang L, Goh KL, Khng HH, Goh SK, Yeo P, Liu X, Bonday Z, Wood JM, Dymock BW, Kantharaj E, Sun ET. Wang H, et al. Among authors: goh kc, goh sk, goh kl. J Med Chem. 2011 Jul 14;54(13):4694-720. doi: 10.1021/jm2003552. Epub 2011 Jun 16. J Med Chem. 2011. PMID: 21634430
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.
Wang H, Yu N, Song H, Chen D, Zou Y, Deng W, Lye PL, Chang J, Ng M, Sun ET, Sangthongpitag K, Wang X, Wu X, Khng HH, Fang L, Goh SK, Ong WC, Bonday Z, Stünkel W, Poulsen A, Entzeroth M. Wang H, et al. Among authors: goh sk. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1403-8. doi: 10.1016/j.bmcl.2009.01.041. Epub 2009 Jan 19. Bioorg Med Chem Lett. 2009. PMID: 19181524
Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma.
William AD, Lee AC, Blanchard S, Poulsen A, Teo EL, Nagaraj H, Tan E, Chen D, Williams M, Sun ET, Goh KC, Ong WC, Goh SK, Hart S, Jayaraman R, Pasha MK, Ethirajulu K, Wood JM, Dymock BW. William AD, et al. Among authors: goh kc, goh sk. J Med Chem. 2011 Jul 14;54(13):4638-58. doi: 10.1021/jm200326p. Epub 2011 Jun 15. J Med Chem. 2011. PMID: 21604762
Developmental language disorder: a hidden condition.
Norbury C, Griffiths S, Goh SKY, Boyes M, Hill E, Viding E. Norbury C, et al. Among authors: goh sky. Lancet Child Adolesc Health. 2024 Feb 5:S2352-4642(24)00016-6. doi: 10.1016/S2352-4642(24)00016-6. Online ahead of print. Lancet Child Adolesc Health. 2024. PMID: 38330984 No abstract available.
Point-of-care detection of fibrosis in liver transplant surgery using near-infrared spectroscopy and machine learning.
Sharma VJ, Adegoke JA, Fasulakis M, Green A, Goh SK, Peng X, Liu Y, Jackett L, Vago A, Poon EKW, Starkey G, Moshfegh S, Muthya A, D'Costa R, James F, Gordon CL, Jones R, Afara IO, Wood BR, Raman J. Sharma VJ, et al. Among authors: goh sk. Health Sci Rep. 2023 Oct 31;6(11):e1652. doi: 10.1002/hsr2.1652. eCollection 2023 Nov. Health Sci Rep. 2023. PMID: 37920655 Free PMC article.
Graft-derived cfDNA Monitoring in Plasma and Bile During Normothermic Machine Perfusion in Liver Transplantation Is Feasible and a Potential Tool for Assessing Graft Viability.
Cox DRA, Lee E, Wong BKL, McClure T, Zhang F, Goh SK, Vago A, Jackett L, Fink M, Jones R, Perini MV, Dobrovic A, Testro A, Starkey G, Muralidharan V. Cox DRA, et al. Among authors: goh sk. Transplantation. 2024 Apr 1;108(4):958-962. doi: 10.1097/TP.0000000000004842. Epub 2023 Oct 30. Transplantation. 2024. PMID: 37902630 Free PMC article.
149 results