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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. Hirschey MD, et al. Among authors: goetzman e. Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778. Nature. 2010. PMID: 20203611 Free PMC article.
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, Farese RV Jr, Kahn CR, Verdin E. Hirschey MD, et al. Among authors: goetzman e. Mol Cell. 2011 Oct 21;44(2):177-90. doi: 10.1016/j.molcel.2011.07.019. Mol Cell. 2011. PMID: 21856199 Free PMC article.
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.
Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J. Peek CB, et al. Among authors: goetzman e. Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19. Science. 2013. PMID: 24051248 Free PMC article.
Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.
Edmunds LR, Otero PA, Sharma L, D'Souza S, Dolezal JM, David S, Lu J, Lamm L, Basantani M, Zhang P, Sipula IJ, Li L, Zeng X, Ding Y, Ding F, Beck ME, Vockley J, Monga SP, Kershaw EE, O'Doherty RM, Kratz LE, Yates NA, Goetzman EP, Scott D, Duncan AW, Prochownik EV. Edmunds LR, et al. Among authors: goetzman ep. Oncotarget. 2016 May 24;7(21):30379-95. doi: 10.18632/oncotarget.8856. Oncotarget. 2016. PMID: 27105497 Free PMC article.
Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury.
Pfister K, Young V, Frankel B, Silva Barbosa A, Burton J, Bons J, Zhang B, Chiba T, Uhlean R, Goetzman E, Schilling B, Sims-Lucas S. Pfister K, et al. Among authors: goetzman e. Am J Physiol Renal Physiol. 2024 May 2. doi: 10.1152/ajprenal.00062.2024. Online ahead of print. Am J Physiol Renal Physiol. 2024. PMID: 38695076
Dietary dicarboxylic acids provide a non-storable alternative fat source that protects mice against obesity.
Goetzman ES, Zhang BB, Zhang Y, Bharathi SS, Bons J, Rose J, Shah S, Solo KJ, Schmidt AV, Richert AC, Mullett SJ, Gelhaus SL, Rao KS, Shiva SS, Pfister KE, Silva Barbosa A, Sims-Lucas S, Dobrowolski SF, Schilling B. Goetzman ES, et al. J Clin Invest. 2024 Apr 30:e174186. doi: 10.1172/JCI174186. Online ahead of print. J Clin Invest. 2024. PMID: 38687608 Free article.
Mitigation of Fetal Irradiation Injury from Mid-Gestation Total Body Radiation with Mitochondrial-Targeted GS-Nitroxide JP4-039.
Wu YL, Christodoulou AG, Beumer JH, Rigatti LH, Fisher R, Ross M, Watkins S, Cortes DRE, Ruck C, Manzoor S, Wyman SK, Stapleton MC, Goetzman E, Bharathi S, Wipf P, Tan T, Eiseman JL, Christner SM, Guo J, Lo CWY, Epperly MW, Greenberger JS. Wu YL, et al. Among authors: goetzman e. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.580105. doi: 10.1101/2024.02.13.580105. bioRxiv. 2024. PMID: 38405696 Free PMC article. Preprint.
Dicarboxylic Acid Dietary Supplementation Protects against AKI.
Silva Barbosa AC, Pfister KE, Chiba T, Bons J, Rose JP, Burton JB, King CD, O'Broin A, Young V, Zhang B, Sivakama B, Schmidt AV, Uhlean R, Oda A, Schilling B, Goetzman ES, Sims-Lucas S. Silva Barbosa AC, et al. Among authors: goetzman es. J Am Soc Nephrol. 2024 Feb 1;35(2):135-148. doi: 10.1681/ASN.0000000000000266. Epub 2023 Dec 4. J Am Soc Nephrol. 2024. PMID: 38044490
87 results