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Page 1
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Ridder BJ, Leishman DJ, Bridgland-Taylor M, Samieegohar M, Han X, Wu WW, Randolph A, Tran P, Sheng J, Danker T, Lindqvist A, Konrad D, Hebeisen S, Polonchuk L, Gissinger E, Renganathan M, Koci B, Wei H, Fan J, Levesque P, Kwagh J, Imredy J, Zhai J, Rogers M, Humphries E, Kirby R, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Himmel H, Mirams GR, Strauss DG, Bardenet R, Li Z. Ridder BJ, et al. Among authors: goetze ta. Toxicol Appl Pharmacol. 2020 May 1;394:114961. doi: 10.1016/j.taap.2020.114961. Epub 2020 Mar 21. Toxicol Appl Pharmacol. 2020. PMID: 32209365 Free PMC article.
Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module.
Obergrussberger A, Brüggemann A, Goetze TA, Rapedius M, Haarmann C, Rinke I, Becker N, Oka T, Ohtsuki A, Stengel T, Vogel M, Steindl J, Mueller M, Stiehler J, George M, Fertig N. Obergrussberger A, et al. Among authors: goetze ta. J Lab Autom. 2016 Dec;21(6):779-793. doi: 10.1177/2211068215623209. Epub 2015 Dec 23. J Lab Autom. 2016. PMID: 26702021
An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery.
Obergrussberger A, Goetze TA, Brinkwirth N, Becker N, Friis S, Rapedius M, Haarmann C, Rinke-Weiß I, Stölzle-Feix S, Brüggemann A, George M, Fertig N. Obergrussberger A, et al. Among authors: goetze ta. Expert Opin Drug Discov. 2018 Mar;13(3):269-277. doi: 10.1080/17460441.2018.1428555. Epub 2018 Jan 17. Expert Opin Drug Discov. 2018. PMID: 29343120 Review.
[No title available]
[No authors listed] [No authors listed] PMID: 31962911
Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961].
Ridder BJ, Leishman DJ, Bridgland-Taylor M, Samieegohar M, Han X, Wu WW, Randolph A, Tran P, Sheng J, Danker T, Lindqvist A, Konrad D, Hebeisen S, Polonchuk L, Gissinger E, Renganathan M, Koci B, Wei H, Fan J, Levesque P, Kwagh J, Imredy J, Zhai J, Rogers M, Humphries E, Kirby R, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Himmel H, Mirams GR, Strauss DG, Bardenet R, Li Z. Ridder BJ, et al. Among authors: goetze ta. Toxicol Appl Pharmacol. 2020 May 15;395:114983. doi: 10.1016/j.taap.2020.114983. Epub 2020 Apr 2. Toxicol Appl Pharmacol. 2020. PMID: 32247767 Free PMC article. No abstract available.
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model.
Han X, Samieegohar M, Ridder BJ, Wu WW, Randolph A, Tran P, Sheng J, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Strauss DG, Li Z. Han X, et al. Among authors: goetze ta. J Pharmacol Toxicol Methods. 2020 Sep;105:106890. doi: 10.1016/j.vascn.2020.106890. Epub 2020 Jun 21. J Pharmacol Toxicol Methods. 2020. PMID: 32574700 Free article.
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
Rotordam MG, Obergrussberger A, Brinkwirth N, Takasuna K, Becker N, Horváth A, Goetze TA, Rapedius M, Furukawa H, Hasegawa Y, Oka T, Fertig N, Stoelzle-Feix S. Rotordam MG, et al. Among authors: goetze ta. J Pharmacol Toxicol Methods. 2021 Nov-Dec;112:107125. doi: 10.1016/j.vascn.2021.107125. Epub 2021 Sep 6. J Pharmacol Toxicol Methods. 2021. PMID: 34500078
The suitability of high throughput automated patch clamp for physiological applications.
Obergrussberger A, Rinke-Weiß I, Goetze TA, Rapedius M, Brinkwirth N, Becker N, Rotordam MG, Hutchison L, Madau P, Pau D, Dalrymple D, Braun N, Friis S, Pless SA, Fertig N. Obergrussberger A, et al. Among authors: goetze ta. J Physiol. 2022 Jan;600(2):277-297. doi: 10.1113/JP282107. Epub 2021 Oct 8. J Physiol. 2022. PMID: 34555195 Free article.
There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments.
Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N. Rapedius M, et al. Among authors: goetze ta. Front Mol Neurosci. 2022 Aug 22;15:982316. doi: 10.3389/fnmol.2022.982316. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36072300 Free PMC article.
21 results