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Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.
Annu Rev Neurosci. 2022 Jul 8;45:447-469. doi: 10.1146/annurev-neuro-111020-100834. Epub 2022 Apr 19.
Annu Rev Neurosci. 2022.
PMID: 35440143
Free article.
Review.
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset.
Goertsen D, Flytzanis NC, Goeden N, Chuapoco MR, Cummins A, Chen Y, Fan Y, Zhang Q, Sharma J, Duan Y, Wang L, Feng G, Chen Y, Ip NY, Pickel J, Gradinaru V.
Goertsen D, et al.
Nat Neurosci. 2022 Jan;25(1):106-115. doi: 10.1038/s41593-021-00969-4. Epub 2021 Dec 9.
Nat Neurosci. 2022.
PMID: 34887588
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Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid.
Goertsen D, Goeden N, Flytzanis NC, Gradinaru V.
Goertsen D, et al.
Mol Ther Methods Clin Dev. 2022 Aug 1;26:331-342. doi: 10.1016/j.omtm.2022.07.010. eCollection 2022 Sep 8.
Mol Ther Methods Clin Dev. 2022.
PMID: 35990749
Free PMC article.
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V.
Chen X, et al. Among authors: goertsen d.
Nat Commun. 2023 Jun 8;14(1):3345. doi: 10.1038/s41467-023-38582-7.
Nat Commun. 2023.
PMID: 37291094
Free PMC article.
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Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors.
Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V.
Shay TF, et al. Among authors: goertsen d.
Sci Adv. 2023 Apr 21;9(16):eadg6618. doi: 10.1126/sciadv.adg6618. Epub 2023 Apr 19.
Sci Adv. 2023.
PMID: 37075114
Free PMC article.
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan E, Huang SF, Kumar SR, Arokiaraj CM, Plattner V, Campos LJ, Mich J, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore B, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V.
Chen X, et al. Among authors: goertsen d.
bioRxiv [Preprint]. 2023 Jan 13:2023.01.12.523844. doi: 10.1101/2023.01.12.523844.
bioRxiv. 2023.
PMID: 36711773
Free PMC article.
Updated.
Preprint.
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