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AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset.
Goertsen D, Flytzanis NC, Goeden N, Chuapoco MR, Cummins A, Chen Y, Fan Y, Zhang Q, Sharma J, Duan Y, Wang L, Feng G, Chen Y, Ip NY, Pickel J, Gradinaru V. Goertsen D, et al. Among authors: goeden n. Nat Neurosci. 2022 Jan;25(1):106-115. doi: 10.1038/s41593-021-00969-4. Epub 2021 Dec 9. Nat Neurosci. 2022. PMID: 34887588
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
Seo JW, Ingham ES, Mahakian L, Tumbale S, Wu B, Aghevlian S, Shams S, Baikoghli M, Jain P, Ding X, Goeden N, Dobreva T, Flytzanis NC, Chavez M, Singhal K, Leib R, James ML, Segal DJ, Cheng RH, Silva EA, Gradinaru V, Ferrara KW. Seo JW, et al. Among authors: goeden n. Nat Commun. 2020 Apr 30;11(1):2102. doi: 10.1038/s41467-020-15818-4. Nat Commun. 2020. PMID: 32355221 Free PMC article.
A transient placental source of serotonin for the fetal forebrain.
Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. Bonnin A, et al. Among authors: goeden n. Nature. 2011 Apr 21;472(7343):347-50. doi: 10.1038/nature09972. Nature. 2011. PMID: 21512572 Free PMC article.
Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment.
Muller CL, Anacker AM, Rogers TD, Goeden N, Keller EH, Forsberg CG, Kerr TM, Wender C, Anderson GM, Stanwood GD, Blakely RD, Bonnin A, Veenstra-VanderWeele J. Muller CL, et al. Among authors: goeden n. Neuropsychopharmacology. 2017 Jan;42(2):427-436. doi: 10.1038/npp.2016.166. Epub 2016 Aug 23. Neuropsychopharmacology. 2017. PMID: 27550733 Free PMC article.
15 results