Gnoth MJ - Search Results

1

Pharmacokinetics of the soluble guanylate cyclase activator cinaciguat in individuals with hepatic impairment.

Frey R, Scheerans C, Blunck M, Mück W, Gnoth MJ, Unger S, Schmidt A, Wensing G. Frey R, et al. Among authors: gnoth mj. J Clin Pharmacol. 2012 Nov;52(11):1714-24. doi: 10.1177/0091270011426143. Epub 2011 Dec 12. J Clin Pharmacol. 2012. PMID: 22162535 Clinical Trial.

2

In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban.

Gnoth MJ, Buetehorn U, Muenster U, Schwarz T, Sandmann S. Gnoth MJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):372-80. doi: 10.1124/jpet.111.180240. Epub 2011 Apr 22. J Pharmacol Exp Ther. 2011. PMID: 21515813

3

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.

Kast R, Schirok H, Figueroa-Pérez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hütter J, Lobell M, Zimmermann K, Münter K, Augstein KH, Ehmke H, Stasch JP. Kast R, et al. Among authors: gnoth mj. Br J Pharmacol. 2007 Dec;152(7):1070-80. doi: 10.1038/sj.bjp.0707484. Epub 2007 Oct 15. Br J Pharmacol. 2007. PMID: 17934515 Free PMC article.

4

Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.

Dumitrascu R, Weissmann N, Ghofrani HA, Dony E, Beuerlein K, Schmidt H, Stasch JP, Gnoth MJ, Seeger W, Grimminger F, Schermuly RT. Dumitrascu R, et al. Among authors: gnoth mj. Circulation. 2006 Jan 17;113(2):286-95. doi: 10.1161/CIRCULATIONAHA.105.581405. Epub 2006 Jan 3. Circulation. 2006. PMID: 16391154

5

Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.

Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Evgenov OV, et al. Among authors: gnoth mj. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1138-45. doi: 10.1164/rccm.200707-1121OC. Epub 2007 Sep 13. Am J Respir Crit Care Med. 2007. PMID: 17872487 Free PMC article.

6

A novel PDE2A reporter cell line: characterization of the cellular activity of PDE inhibitors.

Wunder F, Gnoth MJ, Geerts A, Barufe D. Wunder F, et al. Among authors: gnoth mj. Mol Pharm. 2009 Jan-Feb;6(1):326-36. doi: 10.1021/mp800127n. Mol Pharm. 2009. PMID: 19049345

7

In vitro to in vivo comparison of the substrate characteristics of sorafenib tosylate toward P-glycoprotein.

Gnoth MJ, Sandmann S, Engel K, Radtke M. Gnoth MJ, et al. Drug Metab Dispos. 2010 Aug;38(8):1341-6. doi: 10.1124/dmd.110.032052. Epub 2010 Apr 22. Drug Metab Dispos. 2010. PMID: 20413726

8

Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions.

Muenster U, Grieshop B, Ickenroth K, Gnoth MJ. Muenster U, et al. Among authors: gnoth mj. Pharm Res. 2008 Oct;25(10):2320-6. doi: 10.1007/s11095-008-9632-1. Epub 2008 Jun 4. Pharm Res. 2008. PMID: 18523872

9

Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.

Hillisch A, Gericke KM, Allerheiligen S, Roehrig S, Schaefer M, Tersteegen A, Schulz S, Lienau P, Gnoth M, Puetter V, Hillig RC, Heitmeier S. Hillisch A, et al. J Med Chem. 2020 Nov 12;63(21):12574-12594. doi: 10.1021/acs.jmedchem.0c01035. Epub 2020 Oct 27. J Med Chem. 2020. PMID: 33108181 Free article.

10

Volume to dissolve applied dose (VDAD) and apparent dissolution rate (ADR): tools to predict in vivo bioavailability from orally applied drug suspensions.

Muenster U, Pelzetter C, Backensfeld T, Ohm A, Kuhlmann T, Mueller H, Lustig K, Keldenich J, Greschat S, Göller AH, Gnoth MJ. Muenster U, et al. Among authors: gnoth mj. Eur J Pharm Biopharm. 2011 Aug;78(3):522-30. doi: 10.1016/j.ejpb.2011.01.023. Epub 2011 Feb 16. Eur J Pharm Biopharm. 2011. PMID: 21315152

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