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A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Gomez K, Santiago U, Nelson TS, Allen HN, Calderon-Rivera A, Hestehave S, Rodríguez Palma EJ, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang KE, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora PS, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj MI, Korczeniewska OA, Camacho CJ, Khanna R. Gomez K, et al. Among authors: giuvelis d. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2305215120. doi: 10.1073/pnas.2305215120. Epub 2023 Nov 16. Proc Natl Acad Sci U S A. 2023. PMID: 37972067 Free PMC article.
Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels.
Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW. Payne E, et al. Among authors: giuvelis d. J Pain. 2021 Nov;22(11):1530-1544. doi: 10.1016/j.jpain.2021.05.003. Epub 2021 May 21. J Pain. 2021. PMID: 34029686 Free PMC article.
Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration.
Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ. Stevenson GW, et al. Among authors: giuvelis d. Psychopharmacology (Berl). 2020 Apr;237(4):1195-1208. doi: 10.1007/s00213-019-05449-z. Epub 2020 Jan 7. Psychopharmacology (Berl). 2020. PMID: 31912192 Free PMC article.
Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.
Largent-Milnes TM, Brookshire SW, Skinner DP Jr, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Largent-Milnes TM, et al. Among authors: giuvelis d. J Pharmacol Exp Ther. 2013 Oct;347(1):7-19. doi: 10.1124/jpet.113.205245. Epub 2013 Jul 16. J Pharmacol Exp Ther. 2013. PMID: 23860305 Free PMC article.
The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence.
Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. Stevenson GW, et al. Among authors: giuvelis d. Pharmacol Biochem Behav. 2015 May;132:49-55. doi: 10.1016/j.pbb.2015.02.022. Epub 2015 Feb 28. Pharmacol Biochem Behav. 2015. PMID: 25735493 Free PMC article.
Structural Requirements for CNS Active Opioid Glycopeptides.
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Lefever M, et al. Among authors: giuvelis d. J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23. J Med Chem. 2015. PMID: 26125201
17 results