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The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity.
Frison M, Faccenda D, Abeti R, Rigon M, Strobbe D, England-Rendon BS, Cash D, Barnes K, Sadeghian M, Sajic M, Wells LA, Xia D, Giunti P, Smith K, Mortiboys H, Turkheimer FE, Campanella M. Frison M, et al. Among authors: giunti p. Mol Psychiatry. 2021 Jul;26(7):2721-2739. doi: 10.1038/s41380-021-01050-z. Epub 2021 Mar 4. Mol Psychiatry. 2021. PMID: 33664474 Free PMC article.
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA. Manzoni C, et al. Among authors: giunti p. Biochim Biophys Acta. 2013 Dec;1833(12):2900-2910. doi: 10.1016/j.bbamcr.2013.07.020. Epub 2013 Aug 1. Biochim Biophys Acta. 2013. PMID: 23916833 Free PMC article.
Hsp90 Inhibition: A Promising Therapeutic Approach for ARSACS.
Nethisinghe S, Abeti R, Kesavan M, Wigley WC, Giunti P. Nethisinghe S, et al. Among authors: giunti p. Int J Mol Sci. 2021 Oct 29;22(21):11722. doi: 10.3390/ijms222111722. Int J Mol Sci. 2021. PMID: 34769152 Free PMC article.
207 results