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A yeast functional screen predicts new candidate ALS disease genes.
Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Solski JA, Williams KL, Mojsilovic-Petrovic J, Ingre C, Boylan K, Graff-Radford NR, Dickson DW, Clay-Falcone D, Elman L, McCluskey L, Greene R, Kalb RG, Lee VM, Trojanowski JQ, Ludolph A, Robberecht W, Andersen PM, Nicholson GA, Blair IP, King OD, Bonini NM, Van Deerlin V, Rademakers R, Mourelatos Z, Gitler AD. Couthouis J, et al. Among authors: gitler ad. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20881-90. doi: 10.1073/pnas.1109434108. Epub 2011 Nov 7. Proc Natl Acad Sci U S A. 2011. PMID: 22065782 Free PMC article.
Prime time for alpha-synuclein.
Gitler AD, Shorter J. Gitler AD, et al. J Neurosci. 2007 Mar 7;27(10):2433-4. doi: 10.1523/JNEUROSCI.0094-07.2007. J Neurosci. 2007. PMID: 17344380 Free PMC article. No abstract available.
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. Gitler AD, et al. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):145-50. doi: 10.1073/pnas.0710685105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162536 Free PMC article.
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD. Elden AC, et al. Among authors: gitler ad. Nature. 2010 Aug 26;466(7310):1069-75. doi: 10.1038/nature09320. Nature. 2010. PMID: 20740007 Free PMC article.
TDP-43 toxicity in yeast.
Armakola M, Hart MP, Gitler AD. Armakola M, et al. Among authors: gitler ad. Methods. 2011 Mar;53(3):238-45. doi: 10.1016/j.ymeth.2010.11.006. Epub 2010 Nov 27. Methods. 2011. PMID: 21115123 Free PMC article. Review.
168 results