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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer.
Nat Commun. 2022 Mar 7;13(1):1199. doi: 10.1038/s41467-022-28741-7.
Nat Commun. 2022.
PMID: 35256598
Free PMC article.
Inhibitors of BRAF dimers using an allosteric site.
Cotto-Rios XM, Agianian B, Gitego N, Zacharioudakis E, Giricz O, Wu Y, Zou Y, Verma A, Poulikakos PI, Gavathiotis E.
Cotto-Rios XM, et al. Among authors: gitego n.
Nat Commun. 2020 Sep 1;11(1):4370. doi: 10.1038/s41467-020-18123-2.
Nat Commun. 2020.
PMID: 32873792
Free PMC article.
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ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.
Rahmani NE, Ramachandra N, Sahu S, Gitego N, Lopez A, Pradhan K, Bhagat TD, Gordon-Mitchell S, Pena BR, Kazemi M, Rao K, Giricz O, Maqbool SB, Olea R, Zhao Y, Zhang J, Dolatshad H, Tittrea V, Tatwavedi D, Singh S, Lee J, Sun T, Steidl U, Shastri A, Inoue D, Abdel-Wahab O, Pellagatti A, Gavathiotis E, Boultwood J, Verma A.
Rahmani NE, et al. Among authors: gitego n.
Blood Cancer J. 2021 Sep 21;11(9):157. doi: 10.1038/s41408-021-00541-0.
Blood Cancer J. 2021.
PMID: 34548471
Free PMC article.
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North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Shah UA, Chung EY, Giricz O, Pradhan K, Kataoka K, Gordon-Mitchell S, Bhagat TD, Mai Y, Wei Y, Ishida E, Choudhary GS, Joseph A, Rice R, Gitego N, Parrish C, Bartenstein M, Goel S, Mantzaris I, Shastri A, Derman O, Binder A, Gritsman K, Kornblum N, Braunschweig I, Bhagat C, Hall J, Graber A, Ratner L, Wang Y, Ogawa S, Verma A, Ye BH, Janakiram M.
Shah UA, et al. Among authors: gitego n.
Blood. 2018 Oct 4;132(14):1507-1518. doi: 10.1182/blood-2018-01-824607. Epub 2018 Aug 13.
Blood. 2018.
PMID: 30104217
Free PMC article.
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis.
Gitego N, Agianian B, Mak OW, Kumar Mv V, Cheng EH, Gavathiotis E.
Gitego N, et al.
Nat Commun. 2023 Dec 16;14(1):8381. doi: 10.1038/s41467-023-44084-3.
Nat Commun. 2023.
PMID: 38104127
Free PMC article.
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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG.
Gui DY, et al. Among authors: gitego n.
Cell Metab. 2016 Nov 8;24(5):716-727. doi: 10.1016/j.cmet.2016.09.006. Epub 2016 Oct 13.
Cell Metab. 2016.
PMID: 27746050
Free PMC article.
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