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Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor.
Desai J, Patel B, Gite A, Panchal N, Gite S, Argade A, Kumar J, Sachchidanand S, Bandyopadhyay D, Ghoshdastidar K, Patel H, Chatterjee A, Mahapatra J, Sharma M, Giri P, Kumar S, Jain M, Sharma R, Desai R. Desai J, et al. Among authors: gite a. Bioorg Med Chem Lett. 2022 Jun 15;66:128728. doi: 10.1016/j.bmcl.2022.128728. Epub 2022 Apr 9. Bioorg Med Chem Lett. 2022. PMID: 35413417
Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19).
Desai J, Patel B, Darji B, Gite A, Panchal N, Bhosale G, Shedage S, Patel S, Kadam P, Patel G, Kumar Srivastava B, Joharapurkar A, Kshirsagar S, Giri P, Bhayani H, Patel A, Ghoshdastidar K, Bandyopadhyay D, Kumar S, Jain M, Sharma R. Desai J, et al. Among authors: gite a. Bioorg Med Chem Lett. 2021 Dec 1;53:128421. doi: 10.1016/j.bmcl.2021.128421. Epub 2021 Oct 27. Bioorg Med Chem Lett. 2021. PMID: 34718128
18 results