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Perspectives on NMR in drug discovery: a technique comes of age.
Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G. Pellecchia M, et al. Among authors: giralt e. Nat Rev Drug Discov. 2008 Sep;7(9):738-45. doi: 10.1038/nrd2606. Nat Rev Drug Discov. 2008. PMID: 19172689 Free PMC article. Review.
NMR studies of protein-ligand interactions.
Goldflam M, Tarragó T, Gairí M, Giralt E. Goldflam M, et al. Among authors: giralt e. Methods Mol Biol. 2012;831:233-59. doi: 10.1007/978-1-61779-480-3_14. Methods Mol Biol. 2012. PMID: 22167678
A new class of foldamers based on cis-gamma-amino-L-proline.
Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M. Farrera-Sinfreu J, et al. Among authors: giralt e. J Am Chem Soc. 2004 May 19;126(19):6048-57. doi: 10.1021/ja0398621. J Am Chem Soc. 2004. PMID: 15137770
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfó E, Ventura S. Pujols J, et al. Among authors: giralt e. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486. doi: 10.1073/pnas.1804198115. Epub 2018 Sep 24. Proc Natl Acad Sci U S A. 2018. PMID: 30249646 Free PMC article.
347 results