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The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.
Maga G, Ramunno A, Nacci V, Locatelli GA, Spadari S, Fiorini I, Baldanti F, Paolucci S, Zavattoni M, Bergamini A, Galletti B, Muck S, Hubscher U, Giorgi G, Guiso G, Caccia S, Campiani G. Maga G, et al. Among authors: giorgi g. J Biol Chem. 2001 Nov 30;276(48):44653-62. doi: 10.1074/jbc.M106702200. Epub 2001 Sep 25. J Biol Chem. 2001. PMID: 11572864 Free article.
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.
Campiani G, Fiorini I, De Filippis MP, Ciani SM, Garofalo A, Nacci V, Giorgi G, Sega A, Botta M, Chiarini A, Budriesi R, Bruni G, Romeo MR, Manzoni C, Mennini T. Campiani G, et al. Among authors: giorgi g. J Med Chem. 1996 Jul 19;39(15):2922-38. doi: 10.1021/jm960162z. J Med Chem. 1996. PMID: 8709127
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.
Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C. Pellicciari R, et al. Among authors: giorgi g. J Med Chem. 1996 May 24;39(11):2259-69. doi: 10.1021/jm960059+. J Med Chem. 1996. PMID: 8667369
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Bruni G, Romeo MR, Giorgi G, Donati A. Cappelli A, et al. Among authors: giorgi g. J Med Chem. 1999 May 6;42(9):1556-75. doi: 10.1021/jm981112s. J Med Chem. 1999. PMID: 10229626
Effect of acetaminophen on glutathione levels in rat testis and lung.
Micheli L, Cerretani D, Fiaschi AI, Giorgi G, Romeo MR, Runci FM. Micheli L, et al. Among authors: giorgi g. Environ Health Perspect. 1994 Nov;102 Suppl 9(Suppl 9):63-4. doi: 10.1289/ehp.94102s963. Environ Health Perspect. 1994. PMID: 7698087 Free PMC article.
Amiloride pharmacokinetics in rat.
Segre G, Cerretani D, Bruni G, Urso R, Giorgi G. Segre G, et al. Among authors: giorgi g. Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):218-22. doi: 10.1007/BF03189343. Eur J Drug Metab Pharmacokinet. 1998. PMID: 9725485
573 results