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Page 1
Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: giorgadze n. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Tchkonia T, et al. Among authors: giorgadze n. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E267-77. doi: 10.1152/ajpendo.00265.2004. Epub 2004 Sep 21. Am J Physiol Endocrinol Metab. 2005. PMID: 15383371 Free article.
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.
Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. Karagiannides I, et al. Among authors: giorgadze n. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5207-12. doi: 10.1073/pnas.0600821103. Epub 2006 Mar 20. Proc Natl Acad Sci U S A. 2006. PMID: 16549770 Free PMC article.
Sex- and depot-dependent differences in adipogenesis in normal-weight humans.
Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD. Tchoukalova YD, et al. Among authors: giorgadze n. Obesity (Silver Spring). 2010 Oct;18(10):1875-80. doi: 10.1038/oby.2010.56. Epub 2010 Mar 18. Obesity (Silver Spring). 2010. PMID: 20300084 Free PMC article.
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat.
Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach JL, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Schulz TJ, et al. Among authors: giorgadze n. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):143-8. doi: 10.1073/pnas.1010929108. Epub 2010 Dec 20. Proc Natl Acad Sci U S A. 2011. PMID: 21173238 Free PMC article.
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. Zhu Y, et al. Among authors: giorgadze n. Aging Cell. 2015 Aug;14(4):644-58. doi: 10.1111/acel.12344. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25754370 Free PMC article.
Inflammation and the depot-specific secretome of human preadipocytes.
Zhu Y, Tchkonia T, Stout MB, Giorgadze N, Wang L, Li PW, Heppelmann CJ, Bouloumié A, Jensen MD, Bergen HR 3rd, Kirkland JL. Zhu Y, et al. Among authors: giorgadze n. Obesity (Silver Spring). 2015 May;23(5):989-99. doi: 10.1002/oby.21053. Epub 2015 Apr 10. Obesity (Silver Spring). 2015. PMID: 25864718 Free PMC article.
Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue.
Sagar G, Sah RP, Javeed N, Dutta SK, Smyrk TC, Lau JS, Giorgadze N, Tchkonia T, Kirkland JL, Chari ST, Mukhopadhyay D. Sagar G, et al. Among authors: giorgadze n. Gut. 2016 Jul;65(7):1165-74. doi: 10.1136/gutjnl-2014-308350. Epub 2015 Apr 28. Gut. 2016. PMID: 26061593 Free PMC article.
36 results