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Page 1
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Di Capua A, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Ghelardini C, Di Cesare Mannelli L, Giordani A, Persiani S, Colovic M, Dovizio M, Patrignani P, Anzini M. Biava M, et al. Among authors: giordani a. Bioorg Med Chem. 2014 Jan 15;22(2):772-86. doi: 10.1016/j.bmc.2013.12.008. Epub 2013 Dec 18. Bioorg Med Chem. 2014. PMID: 24373735
The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.
Martelli A, Testai L, Anzini M, Cappelli A, Di Capua A, Biava M, Poce G, Consalvi S, Giordani A, Caselli G, Rovati L, Ghelardini C, Patrignani P, Sautebin L, Breschi MC, Calderone V. Martelli A, et al. Among authors: giordani a. Pharmacol Res. 2013 Dec;78:1-9. doi: 10.1016/j.phrs.2013.09.008. Epub 2013 Sep 29. Pharmacol Res. 2013. PMID: 24083950
Progress towards the identification of new aggrecanase inhibitors.
De Rienzo F, Saxena P, Filomia F, Caselli G, Colace F, Stasi L, Giordani A, Menziani MC. De Rienzo F, et al. Among authors: giordani a. Curr Med Chem. 2009;16(19):2395-415. doi: 10.2174/092986709788682092. Curr Med Chem. 2009. PMID: 19601788 Review.
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases.
Anzini M, Chelini A, Mancini A, Cappelli A, Frosini M, Ricci L, Valoti M, Magistretti J, Castelli L, Giordani A, Makovec F, Vomero S. Anzini M, et al. Among authors: giordani a. J Med Chem. 2010 Jan 28;53(2):734-44. doi: 10.1021/jm901375r. J Med Chem. 2010. PMID: 19950903
Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.
Biava M, Porretta GC, Poce G, Battilocchio C, Botta M, Manetti F, Rovini M, Cappelli A, Sautebin L, Rossi A, Pergola C, Ghelardini C, Galeotti N, Makovec F, Giordani A, Anzellotti P, Tacconelli S, Patrignani P, Anzini M. Biava M, et al. Among authors: giordani a. Curr Med Chem. 2011;18(10):1540-54. doi: 10.2174/092986711795328364. Curr Med Chem. 2011. PMID: 21428878 Free article. Review.
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.
Anzini M, Di Capua A, Valenti S, Brogi S, Rovini M, Giuliani G, Cappelli A, Vomero S, Chiasserini L, Sega A, Poce G, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Benetti V, Giordani A, Anzellotti P, Dovizio M, Patrignani P, Biava M. Anzini M, et al. Among authors: giordani a. J Med Chem. 2013 Apr 25;56(8):3191-206. doi: 10.1021/jm301370e. Epub 2013 Apr 11. J Med Chem. 2013. PMID: 23534442
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Biava M, Battilocchio C, Poce G, Alfonso S, Consalvi S, Porretta GC, Schenone S, Calderone V, Martelli A, Testai L, Ghelardini C, Di Cesare Mannelli L, Sautebin L, Rossi A, Giordani A, Patrignani P, Anzini M. Biava M, et al. Among authors: giordani a. Eur J Med Chem. 2012 Dec;58:287-98. doi: 10.1016/j.ejmech.2012.10.014. Epub 2012 Oct 18. Eur J Med Chem. 2012. PMID: 23131542
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.
Anzini M, Rovini M, Cappelli A, Vomero S, Manetti F, Botta M, Sautebin L, Rossi A, Pergola C, Ghelardini C, Norcini M, Giordani A, Makovec F, Anzellotti P, Patrignani P, Biava M. Anzini M, et al. Among authors: giordani a. J Med Chem. 2008 Aug 14;51(15):4476-81. doi: 10.1021/jm800084s. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598017
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Battilocchio C, Poce G, Alfonso S, Porretta GC, Consalvi S, Sautebin L, Pace S, Rossi A, Ghelardini C, Di Cesare Mannelli L, Schenone S, Giordani A, Di Francesco L, Patrignani P, Biava M. Battilocchio C, et al. Among authors: giordani a. Bioorg Med Chem. 2013 Jul 1;21(13):3695-701. doi: 10.1016/j.bmc.2013.04.031. Epub 2013 Apr 26. Bioorg Med Chem. 2013. PMID: 23680444
122 results