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Are sigma receptor modulators a weapon against multiple sclerosis disease?
Collina S, Rui M, Stotani S, Bignardi E, Rossi D, Curti D, Giordanetto F, Malacrida A, Scuteri A, Cavaletti G. Collina S, et al. Among authors: giordanetto f. Future Med Chem. 2017 Nov;9(17):2029-2051. doi: 10.4155/fmc-2017-0122. Epub 2017 Oct 27. Future Med Chem. 2017. PMID: 29076758
Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT.
Kaitsiotou H, Keul M, Hardick J, Mühlenberg T, Ketzer J, Ehrt C, Krüll J, Medda F, Koch O, Giordanetto F, Bauer S, Rauh D. Kaitsiotou H, et al. Among authors: giordanetto f. J Med Chem. 2017 Nov 9;60(21):8801-8815. doi: 10.1021/acs.jmedchem.7b00841. Epub 2017 Oct 24. J Med Chem. 2017. PMID: 28991465
Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR).
Francesconi V, Giovannini L, Santucci M, Cichero E, Costi MP, Naesens L, Giordanetto F, Tonelli M. Francesconi V, et al. Among authors: giordanetto f. Eur J Med Chem. 2018 Jul 15;155:229-243. doi: 10.1016/j.ejmech.2018.05.059. Epub 2018 Jun 2. Eur J Med Chem. 2018. PMID: 29886325 Free PMC article.
Fragment Hits: What do They Look Like and How do They Bind?
Giordanetto F, Jin C, Willmore L, Feher M, Shaw DE. Giordanetto F, et al. J Med Chem. 2019 Apr 11;62(7):3381-3394. doi: 10.1021/acs.jmedchem.8b01855. Epub 2019 Apr 1. J Med Chem. 2019. PMID: 30875465 Free PMC article.
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
Bach P, Antonsson T, Bylund R, Björkman JA, Österlund K, Giordanetto F, van Giezen JJ, Andersen SM, Zachrisson H, Zetterberg F. Bach P, et al. Among authors: giordanetto f. J Med Chem. 2013 Sep 12;56(17):7015-24. doi: 10.1021/jm400820m. Epub 2013 Aug 29. J Med Chem. 2013. PMID: 23899349
74 results