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Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain.
Marinelli R, Torquato P, Bartolini D, Mas-Bargues C, Bellezza G, Gioiello A, Borras C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Viña J, Leri M, Bucciantini M, Nardiello P, Casamenti F, Galli F. Marinelli R, et al. Among authors: gioiello a. J Biol Chem. 2020 Aug 14;295(33):11866-11876. doi: 10.1074/jbc.RA120.013303. Epub 2020 Jul 2. J Biol Chem. 2020. PMID: 32616652 Free PMC article.
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells.
Gatticchi L, Cerra B, Scarpelli P, Macchioni L, Sebastiani B, Gioiello A, Roberti R. Gatticchi L, et al. Among authors: gioiello a. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):842-852. doi: 10.1016/j.bbalip.2017.05.004. Epub 2017 May 9. Biochim Biophys Acta Mol Cell Biol Lipids. 2017. PMID: 28499814
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schon A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, Mani S, Pellicciari R, Gioiello A, Galli F. Bartolini D, et al. Among authors: gioiello a. J Med Chem. 2020 Apr 9;63(7):3701-3712. doi: 10.1021/acs.jmedchem.0c00012. Epub 2020 Mar 20. J Med Chem. 2020. PMID: 32160459 Free PMC article.
SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione.
Bartolini D, Stabile AM, Bastianelli S, Giustarini D, Pierucci S, Busti C, Vacca C, Gidari A, Francisci D, Castronari R, Mencacci A, Di Cristina M, Focaia R, Sabbatini S, Rende M, Gioiello A, Cruciani G, Rossi R, Galli F. Bartolini D, et al. Among authors: gioiello a. Redox Biol. 2021 Sep;45:102041. doi: 10.1016/j.redox.2021.102041. Epub 2021 Jun 10. Redox Biol. 2021. PMID: 34146958 Free PMC article.
84 results