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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.
Walejko JM, Christopher BA, Crown SB, Zhang GF, Pickar-Oliver A, Yoneshiro T, Foster MW, Page S, van Vliet S, Ilkayeva O, Muehlbauer MJ, Carson MW, Brozinick JT, Hammond CD, Gimeno RE, Moseley MA, Kajimura S, Gersbach CA, Newgard CB, White PJ, McGarrah RW. Walejko JM, et al. Among authors: gimeno re. Nat Commun. 2021 Mar 15;12(1):1680. doi: 10.1038/s41467-021-21962-2. Nat Commun. 2021. PMID: 33723250 Free PMC article.
Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.
White PJ, Lapworth AL, McGarrah RW, Kwee LC, Crown SB, Ilkayeva O, An J, Carson MW, Christopher BA, Ball JR, Davies MN, Kjalarsdottir L, George T, Muehlbauer MJ, Bain JR, Stevens RD, Koves TR, Muoio DM, Brozinick JT, Gimeno RE, Brosnan MJ, Rolph TP, Kraus WE, Shah SH, Newgard CB. White PJ, et al. Among authors: gimeno re. Cell Rep. 2020 Nov 10;33(6):108375. doi: 10.1016/j.celrep.2020.108375. Cell Rep. 2020. PMID: 33176135 Free PMC article.
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Among authors: gimeno re. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, D'Alessio DA, Haupt A. Coskun T, et al. Among authors: gimeno re. Mol Metab. 2018 Dec;18:3-14. doi: 10.1016/j.molmet.2018.09.009. Epub 2018 Oct 3. Mol Metab. 2018. PMID: 30473097 Free PMC article. Clinical Trial.
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.
Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, O'Farrell LS, Briere DA, Sloop KW, Thomas MK, Pirro V, Wainscott DB, Willard FS, Abernathy M, Morford L, Du Y, Benson C, Gimeno RE, Haupt A, Milicevic Z. Coskun T, et al. Among authors: gimeno re. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9. doi: 10.1016/j.cmet.2022.07.013. Epub 2022 Aug 18. Cell Metab. 2022. PMID: 35985340 Free article.
FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency.
Dollet L, Levrel C, Coskun T, Le Lay S, Le May C, Ayer A, Venara Q, Adams AC, Gimeno RE, Magré J, Cariou B, Prieur X. Dollet L, et al. Among authors: gimeno re. Diabetes. 2016 Nov;65(11):3410-3417. doi: 10.2337/db16-0327. Epub 2016 Aug 23. Diabetes. 2016. PMID: 27554469
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.
Samms RJ, Smith DP, Cheng CC, Antonellis PP, Perfield JW 2nd, Kharitonenkov A, Gimeno RE, Adams AC. Samms RJ, et al. Among authors: gimeno re. Cell Rep. 2015 May 19;11(7):991-9. doi: 10.1016/j.celrep.2015.04.046. Epub 2015 May 5. Cell Rep. 2015. PMID: 25956583 Free article.
54 results