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A snake toxin as a theranostic agent for the type 2 vasopressin receptor.
Droctové L, Lancien M, Tran VL, Susset M, Jego B, Theodoro F, Kessler P, Mourier G, Robin P, Diarra SS, Palea S, Flahault A, Chorfa A, Corbani M, Llorens-Cortes C, Mouillac B, Mendre C, Pruvost A, Servent D, Truillet C, Gilles N. Droctové L, et al. Among authors: gilles n. Theranostics. 2020 Sep 18;10(25):11580-11594. doi: 10.7150/thno.47485. eCollection 2020. Theranostics. 2020. PMID: 33052234 Free PMC article.
From a Cone Snail Toxin to a Competitive MC4R Antagonist.
Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles N. Reynaud S, et al. Among authors: gilles n. J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5. J Med Chem. 2022. PMID: 36063022
MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries.
Ciolek J, Zoukimian C, Dhot J, Burban M, Triquigneaux M, Lauzier B, Guimbert C, Boturyn D, Ferron M, Ciccone L, Tepshi L, Stura E, Legrand P, Robin P, Mourier G, Schaack B, Fellah I, Blanchet G, Gauthier-Erfanian C, Beroud R, Servent D, De Waard M, Gilles N. Ciolek J, et al. Among authors: gilles n. Biomed Pharmacother. 2022 Jun;150:113094. doi: 10.1016/j.biopha.2022.113094. Epub 2022 May 10. Biomed Pharmacother. 2022. PMID: 35658242 Free article.
The European FP7 Venomics Project.
Gilles N, Servent D. Gilles N, et al. Future Med Chem. 2014 Oct;6(15):1611-2. doi: 10.4155/fmc.14.85. Future Med Chem. 2014. PMID: 25406001 Free article. No abstract available.
A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Brás JLA, Meudal H, Cabo Díez M, Fernández Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Mörl K, Landon C, Fontes CMGA, Miñambres Herráiz R, Rodríguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N. Reynaud S, et al. Among authors: gilles n. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32602722
101 results