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Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4.
AAPS J. 2019 Jan 9;21(2):15. doi: 10.1208/s12248-018-0262-1.
AAPS J. 2019.
PMID: 30627802
Cytochrome P450-Mediated Biotransformation of Sorafenib and Its N-Oxide Metabolite: Implications for Cell Viability and Human Toxicity.
Gillani TB, Rawling T, Murray M.
Gillani TB, et al.
Chem Res Toxicol. 2015 Jan 20;28(1):92-102. doi: 10.1021/tx500373g. Epub 2014 Dec 23.
Chem Res Toxicol. 2015.
PMID: 25489883
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Differential effects of hepatic cirrhosis on the intrinsic clearances of sorafenib and imatinib by CYPs in human liver.
Murray M, Gillani TB, Ghassabian S, Edwards RJ, Rawling T.
Murray M, et al. Among authors: gillani tb.
Eur J Pharm Sci. 2018 Mar 1;114:55-63. doi: 10.1016/j.ejps.2017.12.003. Epub 2017 Dec 7.
Eur J Pharm Sci. 2018.
PMID: 29223619
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Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of Sorafenib.
Murray M, Gillani TB, Rawling T, Nair PC.
Murray M, et al. Among authors: gillani tb.
AAPS J. 2019 Oct 21;21(6):107. doi: 10.1208/s12248-019-0374-2.
AAPS J. 2019.
PMID: 31637538
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Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite.
Nair PC, Gillani TB, Rawling T, Murray M.
Nair PC, et al. Among authors: gillani tb.
Chem Biol Interact. 2021 Apr 1;338:109401. doi: 10.1016/j.cbi.2021.109401. Epub 2021 Feb 5.
Chem Biol Interact. 2021.
PMID: 33556367
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Anti-proliferative actions of N'-desmethylsorafenib in human breast cancer cells.
Cui PH, Rawling T, Gillani TB, Bourget K, Wang XS, Zhou F, Murray M.
Cui PH, et al. Among authors: gillani tb.
Biochem Pharmacol. 2013 Aug 1;86(3):419-27. doi: 10.1016/j.bcp.2013.05.014. Epub 2013 May 31.
Biochem Pharmacol. 2013.
PMID: 23732299
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