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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A. Abakir A, et al. Among authors: giles tc. Nat Genet. 2020 Jan;52(1):48-55. doi: 10.1038/s41588-019-0549-x. Epub 2019 Dec 16. Nat Genet. 2020. PMID: 31844323 Free PMC article.
LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.
Blythe MJ, Kocer A, Rubio-Roldan A, Giles T, Abakir A, Ialy-Radio C, Wheldon LM, Bereshchenko O, Bruscoli S, Kondrashov A, Drevet JR, Emes RD, Johnson AD, McCarrey JR, Gackowski D, Olinski R, Cocquet J, Garcia-Perez JL, Ruzov A. Blythe MJ, et al. Commun Biol. 2021 Jun 7;4(1):691. doi: 10.1038/s42003-021-02217-8. Commun Biol. 2021. PMID: 34099857 Free PMC article.
Inferring Function from Homology.
Giles TC, Emes RD. Giles TC, et al. Methods Mol Biol. 2017;1526:23-40. doi: 10.1007/978-1-4939-6613-4_2. Methods Mol Biol. 2017. PMID: 27896734
The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits.
Parameswaran N, Dewals BG, Giles TC, Deppmann C, Blythe M, Vanderplasschen A, Emes RD, Haig D. Parameswaran N, et al. Among authors: giles tc. Virus Res. 2014 Aug 8;188:68-80. doi: 10.1016/j.virusres.2014.04.003. Epub 2014 Apr 13. Virus Res. 2014. PMID: 24732177 Free PMC article.
Mutations in the gene encoding IFT dynein complex component WDR34 cause Jeune asphyxiating thoracic dystrophy.
Schmidts M, Vodopiutz J, Christou-Savina S, Cortés CR, McInerney-Leo AM, Emes RD, Arts HH, Tüysüz B, D'Silva J, Leo PJ, Giles TC, Oud MM, Harris JA, Koopmans M, Marshall M, Elçioglu N, Kuechler A, Bockenhauer D, Moore AT, Wilson LC, Janecke AR, Hurles ME, Emmet W, Gardiner B, Streubel B, Dopita B, Zankl A, Kayserili H, Scambler PJ, Brown MA, Beales PL, Wicking C; UK10K; Duncan EL, Mitchison HM. Schmidts M, et al. Among authors: giles tc. Am J Hum Genet. 2013 Nov 7;93(5):932-44. doi: 10.1016/j.ajhg.2013.10.003. Epub 2013 Oct 31. Am J Hum Genet. 2013. PMID: 24183451 Free PMC article.
16 results