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Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss.
Cell Death Dis. 2022 Nov 18;13(11):971. doi: 10.1038/s41419-022-05380-w.
Cell Death Dis. 2022.
PMID: 36400760
Free PMC article.
Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.
Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE.
Savoy-Burke G, et al. Among authors: gilels fa.
PLoS One. 2014 Sep 29;9(9):e108160. doi: 10.1371/journal.pone.0108160. eCollection 2014.
PLoS One. 2014.
PMID: 25264928
Free PMC article.
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Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse.
Paquette ST, Gilels F, White PM.
Paquette ST, et al.
Sci Rep. 2016 May 10;6:25056. doi: 10.1038/srep25056.
Sci Rep. 2016.
PMID: 27162161
Free PMC article.
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Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure.
Gilels F, Paquette ST, Beaulac HJ, Bullen A, White PM.
Gilels F, et al.
Sci Rep. 2017 Apr 21;7(1):1054. doi: 10.1038/s41598-017-01142-3.
Sci Rep. 2017.
PMID: 28432353
Free PMC article.
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Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice.
Beaulac HJ, Gilels F, Zhang J, Jeoung S, White PM.
Beaulac HJ, et al.
Cell Death Dis. 2021 Jul 7;12(7):682. doi: 10.1038/s41419-021-03972-6.
Cell Death Dis. 2021.
PMID: 34234110
Free PMC article.
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Deletion of Notch1 during Cochlear Maturation Leads to Rapid Supporting Cell Death and Profound Deafness.
Heffer A, Gilels FA, Kiernan AE.
Heffer A, et al. Among authors: gilels fa.
J Neurosci. 2023 Jan 11;43(2):199-210. doi: 10.1523/JNEUROSCI.1090-22.2022. Epub 2022 Nov 23.
J Neurosci. 2023.
PMID: 36418183
Free PMC article.
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Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.
Gilels F, Paquette ST, Zhang J, Rahman I, White PM.
Gilels F, et al.
J Neurosci. 2013 Nov 20;33(47):18409-24. doi: 10.1523/JNEUROSCI.2529-13.2013.
J Neurosci. 2013.
PMID: 24259566
Free PMC article.
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