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Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Couñago RM, Allerston CK, Savitsky P, Azevedo H, Godoi PH, Wells CI, Mascarello A, de Souza Gama FH, Massirer KB, Zuercher WJ, Guimarães CRW, Gileadi O. Couñago RM, et al. Among authors: gileadi o. Sci Rep. 2017 Aug 8;7(1):7501. doi: 10.1038/s41598-017-07755-y. Sci Rep. 2017. PMID: 28790404 Free PMC article.
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: gileadi o. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501
Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.
Keates T, Cooper CD, Savitsky P, Allerston CK, Phillips C, Hammarström M, Daga N, Berridge G, Mahajan P, Burgess-Brown NA, Müller S, Gräslund S, Gileadi O. Keates T, et al. Among authors: gileadi o. N Biotechnol. 2012 Jun 15;29(5):515-25. doi: 10.1016/j.nbt.2011.10.007. Epub 2011 Oct 19. N Biotechnol. 2012. PMID: 22027370 Free PMC article.
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.
Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ. Sengerová B, et al. Among authors: gileadi o. J Biol Chem. 2012 Jul 27;287(31):26254-67. doi: 10.1074/jbc.M112.367243. Epub 2012 Jun 11. J Biol Chem. 2012. PMID: 22692201 Free PMC article.
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID. Nguyen GH, et al. Among authors: gileadi o. Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016. Chem Biol. 2013. PMID: 23352139 Free PMC article.
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, Krojer T, Pilka ES, Kiyani W, Lee WH, Marsden BD, von Delft F, Allerston CK, Spagnolo L, Gileadi O, Montelione GT, Oppermann U, Yue WW, Tong L. Froese DS, et al. Among authors: gileadi o. Structure. 2013 Jul 2;21(7):1182-92. doi: 10.1016/j.str.2013.05.001. Epub 2013 Jun 20. Structure. 2013. PMID: 23791943 Free PMC article.
112 results