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Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer.
Zehner M, Alt M, Ashurov A, Goldsmith JA, Spies R, Weiler N, Lerma J, Gieselmann L, Stöhr D, Gruell H, Schultz EP, Kreer C, Schlachter L, Janicki H, Laib Sampaio K, Stegmann C, Nemetchek MD, Dähling S, Ullrich L, Dittmer U, Witzke O, Koch M, Ryckman BJ, Lotfi R, McLellan JS, Krawczyk A, Sinzger C, Klein F. Zehner M, et al. Among authors: gieselmann l. Immunity. 2023 Nov 14;56(11):2602-2620.e10. doi: 10.1016/j.immuni.2023.10.009. Immunity. 2023. PMID: 37967532
Dynamics and durability of HIV-1 neutralization are determined by viral replication.
Schommers P, Kim DS, Schlotz M, Kreer C, Eggeling R, Hake A, Stecher M, Park J, Radford CE, Dingens AS, Ercanoglu MS, Gruell H, Odidika S, Dahlhaus M, Gieselmann L, Ahmadov E, Lawong RY, Heger E, Knops E, Wyen C, Kümmerle T, Römer K, Scholten S, Wolf T, Stephan C, Suárez I, Raju N, Adhikari A, Esser S, Streeck H, Duerr R, Nanfack AJ, Zolla-Pazner S, Geldmacher C, Geisenberger O, Kroidl A, William W, Maganga L, Ntinginya NE, Georgiev IS, Vehreschild JJ, Hoelscher M, Fätkenheuer G, Lavinder JJ, Bloom JD, Seaman MS, Lehmann C, Pfeifer N, Georgiou G, Klein F. Schommers P, et al. Among authors: gieselmann l. Nat Med. 2023 Nov;29(11):2763-2774. doi: 10.1038/s41591-023-02582-3. Epub 2023 Nov 13. Nat Med. 2023. PMID: 37957379 Free PMC article.
The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm.
Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, Bock F. Hamdorf M, et al. Among authors: gieselmann l. J Mol Cell Biol. 2023 Oct 27:mjad062. doi: 10.1093/jmcb/mjad062. Online ahead of print. J Mol Cell Biol. 2023. PMID: 37891014
Performance of commercial SARS-CoV-2 wild-type and Omicron BA.1 antibody assays compared with pseudovirus neutralization tests.
Habermann E, Frommert LM, Ghannam K, Nguyen My L, Gieselmann L, Tober-Lau P, Klotsche J, Arumahandi de Silva AN, Ten Hagen A, Zernicke J, Kurth F, Sander LE, Klein F, Burmester GR, Biesen R, Albach FN. Habermann E, et al. Among authors: gieselmann l. J Clin Virol. 2023 Aug;165:105518. doi: 10.1016/j.jcv.2023.105518. Epub 2023 Jun 9. J Clin Virol. 2023. PMID: 37354690 Free PMC article.
Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning.
Radford CE, Schommers P, Gieselmann L, Crawford KHD, Dadonaite B, Yu TC, Dingens AS, Overbaugh J, Klein F, Bloom JD. Radford CE, et al. Among authors: gieselmann l. Cell Host Microbe. 2023 Jul 12;31(7):1200-1215.e9. doi: 10.1016/j.chom.2023.05.025. Epub 2023 Jun 15. Cell Host Microbe. 2023. PMID: 37327779 Free PMC article.
Pausing methotrexate prevents impairment of Omicron BA.1 and BA.2 neutralisation after COVID-19 booster vaccination.
Habermann E, Gieselmann L, Tober-Lau P, Klotsche J, Albach FN, Ten Hagen A, Zernicke J, Ahmadov E, Arumahandi de Silva AN, Frommert LM, Kurth F, Sander LE, Burmester GR, Klein F, Biesen R. Habermann E, et al. Among authors: gieselmann l. RMD Open. 2022 Oct;8(2):e002639. doi: 10.1136/rmdopen-2022-002639. RMD Open. 2022. PMID: 36216410 Free PMC article.
26 results