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Page 1
Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.
Funcke JB, Moepps B, Roos J, von Schnurbein J, Verstraete K, Fröhlich-Reiterer E, Kohlsdorf K, Nunziata A, Brandt S, Tsirigotaki A, Dansercoer A, Suppan E, Haris B, Debatin KM, Savvides SN, Farooqi IS, Hussain K, Gierschik P, Fischer-Posovszky P, Wabitsch M. Funcke JB, et al. Among authors: gierschik p. N Engl J Med. 2023 Jun 15;388(24):2253-2261. doi: 10.1056/NEJMoa2204041. N Engl J Med. 2023. PMID: 37314706
Acquired BTK mutations associated with resistance to noncovalent BTK inhibitors.
Qi J, Endres S, Yosifov DY, Tausch E, Dheenadayalan RP, Gao X, Müller A, Schneider C, Mertens D, Gierschik P, Wist M, Jebaraj BMC, Stilgenbauer S. Qi J, et al. Among authors: gierschik p. Blood Adv. 2023 Oct 10;7(19):5698-5702. doi: 10.1182/bloodadvances.2022008955. Blood Adv. 2023. PMID: 36661329 Free PMC article. No abstract available.
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM. Zinngrebe J, et al. Among authors: gierschik p. EMBO Mol Med. 2022 Mar 7;14(3):e14901. doi: 10.15252/emmm.202114901. Epub 2022 Feb 16. EMBO Mol Med. 2022. PMID: 35170849 Free PMC article.
Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia.
Jebaraj BMC, Müller A, Dheenadayalan RP, Endres S, Roessner PM, Seyfried F, Walliser C, Wist M, Qi J, Tausch E, Mertens D, Fox JA, Debatin KM, Meyer LH, Taverna P, Seiffert M, Gierschik P, Stilgenbauer S. Jebaraj BMC, et al. Among authors: gierschik p. Blood. 2022 Feb 10;139(6):859-875. doi: 10.1182/blood.2021011516. Blood. 2022. PMID: 34662393 Free article.
Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells.
Wist M, Meier L, Gutman O, Haas J, Endres S, Zhou Y, Rösler R, Wiese S, Stilgenbauer S, Hobeika E, Henis YI, Gierschik P, Walliser C. Wist M, et al. Among authors: gierschik p. J Biol Chem. 2020 Apr 24;295(17):5717-5736. doi: 10.1074/jbc.RA119.011946. Epub 2020 Mar 17. J Biol Chem. 2020. PMID: 32184360 Free PMC article.
Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations.
Nunziata A, Funcke JB, Borck G, von Schnurbein J, Brandt S, Lennerz B, Moepps B, Gierschik P, Fischer-Posovszky P, Wabitsch M. Nunziata A, et al. Among authors: gierschik p. J Endocr Soc. 2018 Sep 17;3(1):27-41. doi: 10.1210/js.2018-00123. eCollection 2019 Jan 1. J Endocr Soc. 2018. PMID: 30560226 Free PMC article. Review.
Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder.
Walliser C, Wist M, Hermkes E, Zhou Y, Schade A, Haas J, Deinzer J, Désiré L, Li SSC, Stilgenbauer S, Milner JD, Gierschik P. Walliser C, et al. Among authors: gierschik p. Oncotarget. 2018 Sep 28;9(76):34357-34378. doi: 10.18632/oncotarget.26173. eCollection 2018 Sep 28. Oncotarget. 2018. PMID: 30344948 Free PMC article.
Estimated prevalence of potentially damaging variants in the leptin gene.
Nunziata A, Borck G, Funcke JB, Kohlsdorf K, Brandt S, Hinney A, Moepps B, Gierschik P, Debatin KM, Fischer-Posovszky P, Wabitsch M. Nunziata A, et al. Among authors: gierschik p. Mol Cell Pediatr. 2017 Nov 3;4(1):10. doi: 10.1186/s40348-017-0074-x. Mol Cell Pediatr. 2017. PMID: 29101506 Free PMC article.
Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency.
Wabitsch M, Pridzun L, Ranke M, von Schnurbein J, Moss A, Brandt S, Kohlsdorf K, Moepps B, Schaab M, Funcke JB, Gierschik P, Fischer-Posovszky P, Flehmig B, Kratzsch J. Wabitsch M, et al. Among authors: gierschik p. Eur J Endocrinol. 2017 Mar;176(3):315-322. doi: 10.1530/EJE-16-0821. Epub 2016 Dec 22. Eur J Endocrinol. 2017. PMID: 28007844 Free PMC article.
176 results