Giembycz MA - Search Results

1

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R. Holden NS, et al. Among authors: giembycz ma. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11. Proc Natl Acad Sci U S A. 2011. PMID: 22080612 Free PMC article.

2

Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.

Kaur M, Holden NS, Wilson SM, Sukkar MB, Chung KF, Barnes PJ, Newton R, Giembycz MA. Kaur M, et al. Among authors: giembycz ma. Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L505-14. doi: 10.1152/ajplung.00046.2008. Epub 2008 Jun 27. Am J Physiol Lung Cell Mol Physiol. 2008. PMID: 18586957 Free article.

3

Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists.

Rider CF, King EM, Holden NS, Giembycz MA, Newton R. Rider CF, et al. Among authors: giembycz ma. J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. doi: 10.1124/jpet.111.181016. Epub 2011 May 27. J Pharmacol Exp Ther. 2011. PMID: 21622733

4

Modulation of transcriptional responses by poly(I:C) and human rhinovirus: effect of long-acting β₂-adrenoceptor agonists.

Rider CF, Miller-Larsson A, Proud D, Giembycz MA, Newton R. Rider CF, et al. Among authors: giembycz ma. Eur J Pharmacol. 2013 May 15;708(1-3):60-7. doi: 10.1016/j.ejphar.2013.02.056. Epub 2013 Mar 20. Eur J Pharmacol. 2013. PMID: 23523474

5

Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R. Holden NS, et al. Among authors: giembycz ma. J Pharmacol Exp Ther. 2014 Jan;348(1):12-24. doi: 10.1124/jpet.113.204586. Epub 2013 Oct 25. J Pharmacol Exp Ther. 2014. PMID: 24163441

6

Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.

Rider CF, Shah S, Miller-Larsson A, Giembycz MA, Newton R. Rider CF, et al. Among authors: giembycz ma. PLoS One. 2015 Jan 27;10(1):e0116773. doi: 10.1371/journal.pone.0116773. eCollection 2015. PLoS One. 2015. PMID: 25625944 Free PMC article.

7

Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.

George T, Bell M, Chakraborty M, Siderovski DP, Giembycz MA, Newton R. George T, et al. Among authors: giembycz ma. PLoS One. 2017 Jan 20;12(1):e0170269. doi: 10.1371/journal.pone.0170269. eCollection 2017. PLoS One. 2017. PMID: 28107494 Free PMC article.

8

Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β ₂-Adrenoceptor Agonist Combination Therapy in Asthma.

Mostafa MM, Rider CF, Wathugala ND, Leigh R, Giembycz MA, Newton R. Mostafa MM, et al. Among authors: giembycz ma. Mol Pharmacol. 2021 Mar;99(3):197-216. doi: 10.1124/molpharm.120.000146. Epub 2020 Dec 29. Mol Pharmacol. 2021. PMID: 33376135

9

An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics.

Joshi T, Johnson M, Newton R, Giembycz M. Joshi T, et al. Br J Pharmacol. 2015 Mar;172(5):1360-78. doi: 10.1111/bph.13014. Epub 2015 Jan 8. Br J Pharmacol. 2015. PMID: 25393397 Free PMC article.

10

Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells.

Kaur M, Chivers JE, Giembycz MA, Newton R. Kaur M, et al. Among authors: giembycz ma. Mol Pharmacol. 2008 Jan;73(1):203-14. doi: 10.1124/mol.107.040121. Epub 2007 Sep 27. Mol Pharmacol. 2008. PMID: 17901197

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