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MYC multimers shield stalled replication forks from RNA polymerase.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Solvie D, et al. Among authors: giansanti c. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23. Nature. 2022. PMID: 36424410
Mdm4 supports DNA replication in a p53-independent fashion.
Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M. Wohlberedt K, et al. Among authors: giansanti c. Oncogene. 2020 Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. Oncogene. 2020. PMID: 32427989 Free PMC article.
Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma.
Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M. Roeschert I, et al. Among authors: giansanti c. Nat Cancer. 2021 Mar;2(3):312-326. doi: 10.1038/s43018-020-00171-8. Epub 2021 Feb 11. Nat Cancer. 2021. PMID: 33768209 Free PMC article.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Papadopoulos D, et al. Among authors: giansanti c. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29. Mol Cell. 2022. PMID: 34847357 Free article.
The interplay of TARG1 and PARG protects against genomic instability.
Groslambert J, Prokhorova E, Wondisford AR, Tromans-Coia C, Giansanti C, Jansen J, Timinszky G, Dobbelstein M, Ahel D, O'Sullivan RJ, Ahel I. Groslambert J, et al. Among authors: giansanti c. Cell Rep. 2023 Sep 26;42(9):113113. doi: 10.1016/j.celrep.2023.113113. Epub 2023 Sep 6. Cell Rep. 2023. PMID: 37676774 Free PMC article.
Sleep-potentiated epileptiform activity in early thalamic injuries: Study in a large series (60 cases).
Losito E, Battaglia D, Chieffo D, Raponi M, Ranalli D, Contaldo I, Giansanti C, De Clemente V, Quintiliani M, Antichi E, Verdolotti T, de Waure C, Tartaglione T, Mercuri E, Guzzetta F. Losito E, et al. Among authors: giansanti c. Epilepsy Res. 2015 Jan;109:90-9. doi: 10.1016/j.eplepsyres.2014.10.015. Epub 2014 Oct 28. Epilepsy Res. 2015. PMID: 25524847
Posterior resection for childhood lesional epilepsy: neuropsychological evolution.
Battaglia D, Chieffo D, Tamburrini G, Lettori D, Losito E, Leo G, Ranalli D, Giansanti C, Antichi E, Caldarelli M, Di Rocco C, Guzzetta F. Battaglia D, et al. Among authors: giansanti c. Epilepsy Behav. 2012 Feb;23(2):131-7. doi: 10.1016/j.yebeh.2011.11.014. Epub 2012 Jan 5. Epilepsy Behav. 2012. PMID: 22225923