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Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.
Ikegami K, de March CA, Nagai MH, Ghosh S, Do M, Sharma R, Bruguera ES, Lu YE, Fukutani Y, Vaidehi N, Yohda M, Matsunami H. Ikegami K, et al. Among authors: ghosh s. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2957-2967. doi: 10.1073/pnas.1915520117. Epub 2020 Jan 23. Proc Natl Acad Sci U S A. 2020. PMID: 31974307 Free PMC article.
Variable G protein determinants of GPCR coupling selectivity.
Okashah N, Wan Q, Ghosh S, Sandhu M, Inoue A, Vaidehi N, Lambert NA. Okashah N, et al. Among authors: ghosh s. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):12054-12059. doi: 10.1073/pnas.1905993116. Epub 2019 May 29. Proc Natl Acad Sci U S A. 2019. PMID: 31142646 Free PMC article.
How Do Branched Detergents Stabilize GPCRs in Micelles?
Lee S, Ghosh S, Jana S, Robertson N, Tate CG, Vaidehi N. Lee S, et al. Among authors: ghosh s. Biochemistry. 2020 Jun 16;59(23):2125-2134. doi: 10.1021/acs.biochem.0c00183. Epub 2020 Jun 5. Biochemistry. 2020. PMID: 32437610 Free PMC article.
A universal allosteric mechanism for G protein activation.
Knight KM, Ghosh S, Campbell SL, Lefevre TJ, Olsen RHJ, Smrcka AV, Valentin NH, Yin G, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: ghosh s. Mol Cell. 2021 Apr 1;81(7):1384-1396.e6. doi: 10.1016/j.molcel.2021.02.002. Epub 2021 Feb 25. Mol Cell. 2021. PMID: 33636126 Free PMC article.
Catalytic site mutations confer multiple states of G protein activation.
Hewitt N, Ma N, Arang N, Martin SA, Prakash A, DiBerto JF, Knight KM, Ghosh S, Olsen RHJ, Roth BL, Gutkind JS, Vaidehi N, Campbell SL, Dohlman HG. Hewitt N, et al. Among authors: ghosh s. Sci Signal. 2023 Feb 14;16(772):eabq7842. doi: 10.1126/scisignal.abq7842. Epub 2023 Feb 14. Sci Signal. 2023. PMID: 36787384 Free PMC article.
13,232 results
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