Ghirlanda G - Search Results

1

The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches.

Woodrum BW, Maxwell JD, Bolia A, Ozkan SB, Ghirlanda G. Woodrum BW, et al. Among authors: ghirlanda g. Biochem Soc Trans. 2013 Oct;41(5):1170-6. doi: 10.1042/BST20130154. Biochem Soc Trans. 2013. PMID: 24059504

2

A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity.

Fromme R, Katiliene Z, Giomarelli B, Bogani F, Mc Mahon J, Mori T, Fromme P, Ghirlanda G. Fromme R, et al. Among authors: ghirlanda g. Biochemistry. 2007 Aug 14;46(32):9199-207. doi: 10.1021/bi700666m. Epub 2007 Jul 18. Biochemistry. 2007. PMID: 17636873

3

Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution.

Fromme R, Katiliene Z, Fromme P, Ghirlanda G. Fromme R, et al. Among authors: ghirlanda g. Protein Sci. 2008 May;17(5):939-44. doi: 10.1110/ps.083472808. Protein Sci. 2008. PMID: 18436959 Free PMC article.

4

Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin.

Liu Y, Carroll JR, Holt LA, McMahon J, Giomarelli B, Ghirlanda G. Liu Y, et al. Among authors: ghirlanda g. Biopolymers. 2009;92(3):194-200. doi: 10.1002/bip.21173. Biopolymers. 2009. PMID: 19235857 Free PMC article.

5

Modulation of function in a minimalist heme-binding membrane protein.

Shinde S, Cordova JM, Woodrum BW, Ghirlanda G. Shinde S, et al. Among authors: ghirlanda g. J Biol Inorg Chem. 2012 Apr;17(4):557-64. doi: 10.1007/s00775-012-0876-1. Epub 2012 Feb 4. J Biol Inorg Chem. 2012. PMID: 22307279

6

A flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding.

Bolia A, Woodrum BW, Cereda A, Ruben MA, Wang X, Ozkan SB, Ghirlanda G. Bolia A, et al. Among authors: ghirlanda g. Biophys J. 2014 Mar 4;106(5):1142-51. doi: 10.1016/j.bpj.2014.01.040. Biophys J. 2014. PMID: 24606938 Free PMC article.

7

A designed buried salt bridge modulates heterodimerization of a membrane peptide.

Shinde S, Binder JK, Goyal B, Woodrum B, De Munari S, Levitus M, Ghirlanda G. Shinde S, et al. Among authors: ghirlanda g. Biopolymers. 2014 Nov;102(6):437-43. doi: 10.1002/bip.22564. Biopolymers. 2014. PMID: 25250823

8

A Rigid Hinge Region Is Necessary for High-Affinity Binding of Dimannose to Cyanovirin and Associated Constructs.

Li Z, Bolia A, Maxwell JD, Bobkov AA, Ghirlanda G, Ozkan SB, Margulis CJ. Li Z, et al. Among authors: ghirlanda g. Biochemistry. 2015 Nov 24;54(46):6951-60. doi: 10.1021/acs.biochem.5b00635. Epub 2015 Nov 12. Biochemistry. 2015. PMID: 26507789

9

A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.

Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G. Woodrum BW, et al. Among authors: ghirlanda g. Viruses. 2016 Jun 6;8(6):158. doi: 10.3390/v8060158. Viruses. 2016. PMID: 27275831 Free PMC article.

10

Rational development of a high-affinity secretin receptor antagonist.

Dong M, Harikumar KG, Raval SR, Milburn JE, Clark C, Alcala-Torano R, Mobarec JC, Reynolds CA, Ghirlanda G, Christopoulos A, Wootten D, Sexton PM, Miller LJ. Dong M, et al. Among authors: ghirlanda g. Biochem Pharmacol. 2020 Jul;177:113929. doi: 10.1016/j.bcp.2020.113929. Epub 2020 Mar 23. Biochem Pharmacol. 2020. PMID: 32217097 Free PMC article.

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