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Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism.
Zafrani Y, Parvari G, Amir D, Ghindes-Azaria L, Elias S, Pevzner A, Fridkin G, Berliner A, Gershonov E, Eichen Y, Saphier S, Katalan S. Zafrani Y, et al. Among authors: ghindes azaria l. J Med Chem. 2021 Apr 22;64(8):4516-4531. doi: 10.1021/acs.jmedchem.0c01868. Epub 2021 Apr 12. J Med Chem. 2021. PMID: 33844540
Studying Lipophilicity Trends of Phosphorus Compounds by 31P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs.
Columbus I, Ghindes-Azaria L, Chen R, Yehezkel L, Redy-Keisar O, Fridkin G, Amir D, Marciano D, Drug E, Gershonov E, Klausner Z, Saphier S, Elias S, Pevzner A, Eichen Y, Parvari G, Smolkin B, Zafrani Y. Columbus I, et al. Among authors: ghindes azaria l. J Med Chem. 2022 Jun 23;65(12):8511-8524. doi: 10.1021/acs.jmedchem.2c00658. Epub 2022 Jun 9. J Med Chem. 2022. PMID: 35678759
Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads.
Columbus I, Ghindes-Azaria L, Herzog IM, Blum E, Parvari G, Eichen Y, Cohen Y, Gershonov E, Drug E, Saphier S, Elias S, Smolkin B, Zafrani Y. Columbus I, et al. Among authors: ghindes azaria l. Commun Chem. 2023 Sep 15;6(1):197. doi: 10.1038/s42004-023-01004-2. Commun Chem. 2023. PMID: 37715018 Free PMC article.
Placing CF2 in the Center: Major Physicochemical Changes Upon a Minor Structural Alteration in Gem-Difunctional Compounds.
Saphier S, Katalan S, Yacov G, Berliner A, Redy-Keisar O, Fridkin G, Ghindes-Azaria L, Columbus I, Pevzner A, Drug E, Prihed H, Gershonov E, Eichen Y, Elias S, Parvari G, Zafrani Y. Saphier S, et al. Among authors: ghindes azaria l. Chemistry. 2023 Feb 1;29(7):e202202939. doi: 10.1002/chem.202202939. Epub 2022 Dec 12. Chemistry. 2023. PMID: 36374157