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Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice.
Liu J, Lane S, Lall R, Russo M, Farrell L, Debreli Coskun M, Curtin C, Araujo-Gutierrez R, Scherrer-Crosbie M, Trachtenberg BH, Kim J, Tolosano E, Ghigo A, Gerszten RE, Asnani A. Liu J, et al. Among authors: ghigo a. Sci Adv. 2022 Dec 23;8(51):eadc9245. doi: 10.1126/sciadv.adc9245. Epub 2022 Dec 23. Sci Adv. 2022. PMID: 36563141 Free PMC article.
Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.
Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR. Zamboni V, et al. Among authors: ghigo a. Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3. Sci Rep. 2018. PMID: 29740022 Free PMC article.
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR. Zamboni V, et al. Among authors: ghigo a. Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877. Sci Rep. 2016. PMID: 27713499 Free PMC article.
Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive.
Perino A, Beretta M, Kilić A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E. Perino A, et al. Among authors: ghigo a. Sci Signal. 2014 Nov 18;7(352):ra110. doi: 10.1126/scisignal.2005485. Sci Signal. 2014. PMID: 25406378
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.
Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B. Shymanets A, et al. Among authors: ghigo a. Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099. Biochem J. 2015. PMID: 26173259 Free PMC article.
Rac signal adaptation controls neutrophil mobilization from the bone marrow.
Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E. Campa CC, et al. Among authors: ghigo a. Sci Signal. 2016 Dec 20;9(459):ra124. doi: 10.1126/scisignal.aah5882. Sci Signal. 2016. PMID: 27999173
Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, Ghigo A, Hirsch E, Jin J, Chow CW. Suk HY, et al. Among authors: ghigo a. J Biol Chem. 2013 Feb 1;288(5):3477-88. doi: 10.1074/jbc.M112.419150. Epub 2012 Dec 20. J Biol Chem. 2013. PMID: 23258544 Free PMC article.
Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.
Alissafi T, Banos A, Boon L, Sparwasser T, Ghigo A, Wing K, Vassilopoulos D, Boumpas D, Chavakis T, Cadwell K, Verginis P. Alissafi T, et al. Among authors: ghigo a. J Clin Invest. 2017 Jun 30;127(7):2789-2804. doi: 10.1172/JCI92079. Epub 2017 Jun 5. J Clin Invest. 2017. PMID: 28581446 Free PMC article.
124 results