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Page 1
Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis.
Sadiku P, Willson JA, Ryan EM, Sammut D, Coelho P, Watts ER, Grecian R, Young JM, Bewley M, Arienti S, Mirchandani AS, Sanchez Garcia MA, Morrison T, Zhang A, Reyes L, Griessler T, Jheeta P, Paterson GG, Graham CJ, Thomson JP, Baillie K, Thompson AAR, Morgan JM, Acosta-Sanchez A, Dardé VM, Duran J, Guinovart JJ, Rodriguez-Blanco G, Von Kriegsheim A, Meehan RR, Mazzone M, Dockrell DH, Ghesquiere B, Carmeliet P, Whyte MKB, Walmsley SR. Sadiku P, et al. Among authors: ghesquiere b. Cell Metab. 2021 May 4;33(5):1062-1064. doi: 10.1016/j.cmet.2021.03.018. Cell Metab. 2021. PMID: 33951466 Free PMC article. No abstract available.
Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression.
Jones R, McDonald KE, Willson JA, Ghesquière B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AA, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MK, Newell-Price J, Walmsley SR. Jones R, et al. Among authors: ghesquiere b. Blood. 2016 May 26;127(21):2641-4. doi: 10.1182/blood-2016-02-696922. Epub 2016 Mar 22. Blood. 2016. PMID: 27006389 Free PMC article. No abstract available.
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.
Wenes M, Shang M, Di Matteo M, Goveia J, Martín-Pérez R, Serneels J, Prenen H, Ghesquière B, Carmeliet P, Mazzone M. Wenes M, et al. Among authors: ghesquiere b. Cell Metab. 2016 Nov 8;24(5):701-715. doi: 10.1016/j.cmet.2016.09.008. Epub 2016 Oct 20. Cell Metab. 2016. PMID: 27773694 Free article.
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR. Sadiku P, et al. Among authors: ghesquiere b. J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14. J Clin Invest. 2017. PMID: 28805660 Free PMC article.
IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.
Harris AJ, Mirchandani AS, Lynch RW, Murphy F, Delaney L, Small D, Coelho P, Watts ER, Sadiku P, Griffith D, Dickinson RS, Clark E, Willson JA, Morrison T, Mazzone M, Carmeliet P, Ghesquiere B, O'Kane C, McAuley D, Jenkins SJ, Whyte MKB, Walmsley SR. Harris AJ, et al. Among authors: ghesquiere b. Am J Respir Crit Care Med. 2019 Jul 15;200(2):235-246. doi: 10.1164/rccm.201808-1599OC. Am J Respir Crit Care Med. 2019. PMID: 30849228 Free PMC article.
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis.
Sadiku P, Willson JA, Ryan EM, Sammut D, Coelho P, Watts ER, Grecian R, Young JM, Bewley M, Arienti S, Mirchandani AS, Sanchez Garcia MA, Morrison T, Zhang A, Reyes L, Griessler T, Jheeta P, Paterson GG, Graham CJ, Thomson JP, Baillie K, Thompson AAR, Morgan JM, Acosta-Sanchez A, Dardé VM, Duran J, Guinovart JJ, Rodriguez-Blanco G, Von Kriegsheim A, Meehan RR, Mazzone M, Dockrell DH, Ghesquiere B, Carmeliet P, Whyte MKB, Walmsley SR. Sadiku P, et al. Among authors: ghesquiere b. Cell Metab. 2021 Feb 2;33(2):411-423.e4. doi: 10.1016/j.cmet.2020.11.016. Epub 2020 Dec 10. Cell Metab. 2021. PMID: 33306983 Free PMC article.
Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism.
Watts ER, Howden AJ, Morrison T, Sadiku P, Hukelmann J, von Kriegsheim A, Ghesquiere B, Murphy F, Mirchandani AS, Humphries DC, Grecian R, Ryan EM, Coelho P, Blanco GR, Plant TM, Dickinson RS, Finch A, Vermaelen W, Cantrell DA, Whyte MK, Walmsley SR. Watts ER, et al. Among authors: ghesquiere b. J Clin Invest. 2021 May 17;131(10):e134073. doi: 10.1172/JCI134073. J Clin Invest. 2021. PMID: 33822765 Free PMC article.
-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--.
Reyes L, A Sanchez-Garcia M, Morrison T, Howden AJM, Watts ER, Arienti S, Sadiku P, Coelho P, Mirchandani AS, Zhang A, Hope D, Clark SK, Singleton J, Johnston S, Grecian R, Poon A, McNamara S, Harper I, Fourman MH, Brenes AJ, Pathak S, Lloyd A, Blanco GR, von Kriegsheim A, Ghesquiere B, Vermaelen W, Cologna CT, Dhaliwal K, Hirani N, Dockrell DH, Whyte MKB, Griffith D, Cantrell DA, Walmsley SR. Reyes L, et al. Among authors: ghesquiere b. Wellcome Open Res. 2021 May 20;6:38. doi: 10.12688/wellcomeopenres.16584.2. eCollection 2021. Wellcome Open Res. 2021. PMID: 33997298 Free PMC article.
NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
Ryan EM, Sadiku P, Coelho P, Watts ER, Zhang A, Howden AJM, Sanchez-Garcia MA, Bewley M, Cole J, McHugh BJ, Vermaelen W, Ghesquiere B, Carmeliet P, Rodriguez Blanco G, Von Kriegsheim A, Sanchez Y, Rumsey W, Callahan JF, Cooper G, Parkinson N, Baillie K, Cantrell DA, McCafferty J, Choudhury G, Singh D, Dockrell DH, Whyte MKB, Walmsley SR. Ryan EM, et al. Among authors: ghesquiere b. Am J Respir Crit Care Med. 2023 Apr 15;207(8):998-1011. doi: 10.1164/rccm.202203-0482OC. Am J Respir Crit Care Med. 2023. PMID: 36724365 Free PMC article.
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Schoors S, De Bock K, Cantelmo AR, Georgiadou M, Ghesquière B, Cauwenberghs S, Kuchnio A, Wong BW, Quaegebeur A, Goveia J, Bifari F, Wang X, Blanco R, Tembuyser B, Cornelissen I, Bouché A, Vinckier S, Diaz-Moralli S, Gerhardt H, Telang S, Cascante M, Chesney J, Dewerchin M, Carmeliet P. Schoors S, et al. Among authors: ghesquiere b. Cell Metab. 2014 Jan 7;19(1):37-48. doi: 10.1016/j.cmet.2013.11.008. Epub 2013 Dec 12. Cell Metab. 2014. PMID: 24332967 Free article.
130 results