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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Nat Chem Biol. 2020 Mar;16(3):240-249. doi: 10.1038/s41589-019-0453-9. Epub 2020 Feb 20.
Nat Chem Biol. 2020.
PMID: 32080630
Free article.
Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor.
Rosethorne EM, Bradley ME, Gherbi K, Sykes DA, Sattikar A, Wright JD, Renard E, Trifilieff A, Fairhurst RA, Charlton SJ.
Rosethorne EM, et al. Among authors: gherbi k.
Mol Pharmacol. 2016 Apr;89(4):467-75. doi: 10.1124/mol.115.101253. Epub 2016 Jan 15.
Mol Pharmacol. 2016.
PMID: 26772612
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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor.
Yen HY, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, Gherbi K, Hopper JTS, Charlton SJ, Politis A, Sansom MSP, Jazayeri A, Robinson CV.
Yen HY, et al. Among authors: gherbi k.
Nat Chem. 2022 Dec;14(12):1375-1382. doi: 10.1038/s41557-022-01041-9. Epub 2022 Nov 10.
Nat Chem. 2022.
PMID: 36357787
Free PMC article.
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Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
Gherbi K, Briddon SJ, Hill SJ.
Gherbi K, et al.
Br J Pharmacol. 2014 Dec;171(23):5431-45. doi: 10.1111/bph.12858.
Br J Pharmacol. 2014.
PMID: 25052258
Free PMC article.
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Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.
Gherbi K, May LT, Baker JG, Briddon SJ, Hill SJ.
Gherbi K, et al.
FASEB J. 2015 Jul;29(7):2859-71. doi: 10.1096/fj.14-265199. Epub 2015 Apr 2.
FASEB J. 2015.
PMID: 25837585
Free PMC article.
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Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes.
Gherbi K, Briddon SJ, Charlton SJ.
Gherbi K, et al.
Sci Rep. 2018 Feb 22;8(1):3479. doi: 10.1038/s41598-018-21100-x.
Sci Rep. 2018.
PMID: 29472588
Free PMC article.
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A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.
Arruda MA, Stoddart LA, Gherbi K, Briddon SJ, Kellam B, Hill SJ.
Arruda MA, et al. Among authors: gherbi k.
Front Pharmacol. 2017 Dec 13;8:908. doi: 10.3389/fphar.2017.00908. eCollection 2017.
Front Pharmacol. 2017.
PMID: 29321740
Free PMC article.
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Sitting with vs. across a patient.
Gherbi K.
Gherbi K.
Asian J Psychiatr. 2015 Apr;14:86-7. doi: 10.1016/j.ajp.2015.04.010.
Asian J Psychiatr. 2015.
PMID: 26025030
No abstract available.
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